Difference between revisions of "Lomustine (CCNU)"
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
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| + | ==Diseases for which it is used== | ||
| + | [[Central nervous system (CNS) cancer]] | ||
| + | [[CNS lymphoma]] | ||
==Patient drug information== | ==Patient drug information== | ||
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[[Category:Chemotherapy]] | [[Category:Chemotherapy]] | ||
[[Category:Nitrosureas]] | [[Category:Nitrosureas]] | ||
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[[Category:Central nervous system (CNS) cancer medications]] | [[Category:Central nervous system (CNS) cancer medications]] | ||
[[Category:Central nervous system (CNS) lymphoma medications]] | [[Category:Central nervous system (CNS) lymphoma medications]] | ||
Revision as of 18:22, 19 September 2014
General information
Class/mechanism: Nitrosourea, alkylates DNA and RNA and may inhibit certain key enzymatic reactions by carbamoylation of amino acids in proteins.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Central nervous system (CNS) cancer CNS lymphoma
Patient drug information
- Lomustine (Ceenu) patient drug information (Chemocare)[3]
- Lomustine (Ceenu) patient drug information (UpToDate)[4]
Also known as
Also known as CCNU.
- In 10/2013, Bristol-Myers Squibb discontinued production of their Lomustine brand name, CeeNu.[5] Lomustine will be supplied as CCNU by NextSource Biotechnology.[6]
References
- ↑ 1.0 1.1 Lomustine (Ceenu) package insert
- ↑ Lomustine (Ceenu) package insert (locally hosted backup)
- ↑ Lomustine (Ceenu) patient drug information (Chemocare)
- ↑ Lomustine (Ceenu) patient drug information (UpToDate)
- ↑ Discontinued drug bulletin: Lomustine capsules (American Society of Health-System Pharmacists)
- ↑ NextSource Biotechnology Lomustine (CCNU) update