Difference between revisions of "Nilotinib (Tasigna)"
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==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
| − | *10/29/2007: Granted FDA accelerated approval for the treatment of chronic phase and accelerated phase Philadelphia chromosome positive chronic myelogenous leukemia (CML) in adult patients resistant to or intolerant to prior therapy that included [[Imatinib (Gleevec)]]. | + | *10/29/2007: Granted FDA accelerated approval for the treatment of chronic phase and accelerated phase Philadelphia chromosome positive [[Chronic myelogenous leukemia | chronic myelogenous leukemia (CML)]] in adult patients resistant to or intolerant to prior therapy that included [[Imatinib (Gleevec)]]. |
| − | *6/17/2010: New indication for the treatment of newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase. | + | *6/17/2010: New indication for the treatment of newly diagnosed adult patients with Philadelphia chromosome positive [[Chronic myelogenous leukemia | chronic myeloid leukemia (Ph+ CML)]] in chronic phase. |
==Also known as== | ==Also known as== | ||
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[[Category:Kinase inhibitors]] | [[Category:Kinase inhibitors]] | ||
[[Category:Bcr-Abl inhibitors]] | [[Category:Bcr-Abl inhibitors]] | ||
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| + | [[Category:Chronic myelogenous leukemia medications]] | ||
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| + | [[Category:Drugs FDA approved in 2007]] | ||
Revision as of 19:35, 8 September 2014
General information
Class/mechanism: Tyrosine kinase inhibitor of Bcr-Abl, the constitutively active tyrosine kinase resulting from the Philadelphia chromosome abnormality in CML. Nilotinib binds to the inactive conformation of the Abl kinase domain and stabilizes it.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Nilotinib (Tasigna) package insert PDF pages 23-27[1]
- Nilotinib (Tasigna) patient drug information (Chemocare)[3]
- Nilotinib (Tasigna) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 10/29/2007: Granted FDA accelerated approval for the treatment of chronic phase and accelerated phase Philadelphia chromosome positive chronic myelogenous leukemia (CML) in adult patients resistant to or intolerant to prior therapy that included Imatinib (Gleevec).
- 6/17/2010: New indication for the treatment of newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase.
Also known as
AMN107