Difference between revisions of "Thrombocytosis"
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==Definition== | ==Definition== | ||
− | Platelet count greater than or equal to 450 × 10<sup>9</sup>/L (''local reference ranges may vary'').<ref>Elisa Rumi and Mario Cazzola. [http://www.bloodjournal.org/content/128/20/2403 How I treat essential thrombocythemia.] Blood 2016 128:2403-2414. [https:// | + | Platelet count greater than or equal to 450 × 10<sup>9</sup>/L (''local reference ranges may vary'').<ref>Elisa Rumi and Mario Cazzola. [http://www.bloodjournal.org/content/128/20/2403 How I treat essential thrombocythemia.] Blood 2016 128:2403-2414. [https://pubmed.ncbi.nlm.nih.gov/27561316 PubMed]</ref> |
==Initial evaluation== | ==Initial evaluation== |
Revision as of 18:59, 3 June 2021
Definition
Platelet count greater than or equal to 450 × 109/L (local reference ranges may vary).[1]
Initial evaluation
May consist of:
- CBC with differential
- Iron, total iron binding capacity (TIBC), ferritin
- JAK2 V617F mutation
- CALR exon 9 indels
- MPL exon 10 mutations
- Peripheral smear
- Splenectomy
- Clinical history (e.g. recent surgery or other reasons for reactive thrombocytosis), lifestyle factors
References
- ↑ Elisa Rumi and Mario Cazzola. How I treat essential thrombocythemia. Blood 2016 128:2403-2414. PubMed