Difference between revisions of "Chlorambucil (Leukeran)"
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
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==Patient drug information== | ==Patient drug information== | ||
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[[Category:Nitrogen mustards]] | [[Category:Nitrogen mustards]] | ||
[[Category:Alkylating agents]] | [[Category:Alkylating agents]] | ||
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[[Category:Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications]] | [[Category:Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications]] | ||
[[Category:Hodgkin lymphoma medications]] | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:Follicular lymphoma medications]] | ||
| + | [[Category:Mantle cell lymphoma medications]] | ||
| + | [[Category:Marginal zone lymphoma medications]] | ||
| + | [[Category:Waldenström macroglobulinemia medications]] | ||
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| + | [[Category:Drugs FDA approved in 1957]] | ||
Revision as of 22:56, 27 June 2014
General information
Class/mechanism: Nitrogen mustard, alkylating agent. Interferes with DNA replication and induces apoptosis through accumulation of p53 in the cytosol and downstream activation of the apoptosis promoter Bax.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Chlorambucil (Leukeran) patient drug information (Chemocare)[3]
- Chlorambucil (Leukeran) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 3/18/1957: Initial FDA approval
Also known as
Precise Name: Chlorambucil (RXCUI 2346)
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Chloraminophene | Chlorambusil | Chlorobutin | Chlorbutin | Leukeran | Linfoxan | ||
References
- Drug index
- Chemotherapy
- Nitrogen mustards
- Alkylating agents
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications
- Hodgkin lymphoma medications
- Follicular lymphoma medications
- Mantle cell lymphoma medications
- Marginal zone lymphoma medications
- Waldenström macroglobulinemia medications
- Drugs FDA approved in 1957