Difference between revisions of "Dacarbazine (DTIC)"
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==General information== | ==General information== | ||
Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Dacarbazine.pdf Dacarbazine (DTIC) package insert]</ref><ref>[[Media:Dacarbazine.pdf | Dacarbazine (DTIC) package insert (locally hosted backup)]]</ref> | Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Dacarbazine.pdf Dacarbazine (DTIC) package insert]</ref><ref>[[Media:Dacarbazine.pdf | Dacarbazine (DTIC) package insert (locally hosted backup)]]</ref> | ||
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
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==Patient drug information== | ==Patient drug information== | ||
*[http://chemocare.com/chemotherapy/drug-info/dacarbazine.aspx Dacarbazine (DTIC) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/dacarbazine.aspx Dacarbazine (DTIC) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/chemotherapy/drug-info/dacarbazine.aspx Dacarbazine (DTIC) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/dacarbazine.aspx Dacarbazine (DTIC) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/dacarbazine-patient-drug-information Dacarbazine (DTIC) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dacarbazine-patient-drug-information Dacarbazine (DTIC) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/dacarbazine-patient-drug-information Dacarbazine (DTIC) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dacarbazine-patient-drug-information Dacarbazine (DTIC) patient drug information (UpToDate)]</ref> | ||
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| + | ==Also known as== | ||
| + | DIC, DTIC-Dome, Imidazole carboxamide | ||
==References== | ==References== | ||
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[[Category:DNA synthesis inhibitors]] | [[Category:DNA synthesis inhibitors]] | ||
[[Category:Nucleic acid analogs]] | [[Category:Nucleic acid analogs]] | ||
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[[Category:Hodgkin lymphoma medications]] | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:Hodgkin lymphoma, nodular lymphocyte-predominant medications]] | ||
[[Category:Melanoma medications]] | [[Category:Melanoma medications]] | ||
| + | [[Category:Neuroendocrine tumor medications]] | ||
| + | [[Category:Sarcoma medications]] | ||
Revision as of 20:44, 11 June 2014
General information
Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.[1][2]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Dacarbazine (DTIC) patient drug information (Chemocare)[3]
- Dacarbazine (DTIC) patient drug information (UpToDate)[4]
Also known as
DIC, DTIC-Dome, Imidazole carboxamide