Difference between revisions of "User talk:Binunair2002"
Jump to navigation
Jump to search
Binunair2002 (talk | contribs) |
Binunair2002 (talk | contribs) |
||
| Line 1: | Line 1: | ||
| − | = | + | = LGL with treatment indications= |
| − | == Methotrexate | + | |
| − | *[[Methotrexate 10mg/m2 weekly po]] + | + | Regimen 1 |
| − | *[[ Prednisone 1mg/kg po daily x one month then taper over 1 months.]] | + | == Methotrexate +/- Prednisone== |
| − | ''' stop if no response by 4 months, if response continue ''' | + | *[[Methotrexate 7.5mg/m2 to 10mg/m2 weekly po]] + |
| + | *[[Prednisone 1mg/kg po daily x one month then taper over 1 months.]] | ||
| + | ''' stop if no response by 4 months, if response continue until progression ''' | ||
| + | |||
| + | Supportive medications: | ||
| + | |||
| + | ===References=== | ||
| + | |||
| + | # Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95(9):1534-1541.[http://www.haematologica.org/content/95/9/1534.long#T3 long link to original article] [http://www.ncbi.nlm.nih.gov/pubmed?term=20378561 pubmed] | ||
| + | # Lamy T, Loughran TP.[http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 ] How I treat LGL leukemia. Blood 2011; 117: 2764–2774.[http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 link to original artcle ][http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 pubmed] | ||
| + | |||
| + | Regimen 1 | ||
| + | ==Cyclophosphamide +/- Prednisone== | ||
| + | *[[ Cyclophosphamide 50-100 mg po daily | ||
| + | '''stop if no response by 4 months, if response continue for 6-12 months ,earlier if progression. Generous po fluid intake to prevent bladder toxicity''' | ||
| + | |||
| + | ===References=== | ||
| + | |||
| + | # Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95(9):1534-1541.[http://www.haematologica.org/content/95/9/1534.long#T3 long link to original article] [http://www.ncbi.nlm.nih.gov/pubmed?term=20378561 pubmed] | ||
| + | # Lamy T, Loughran TP.[http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 ] How I treat LGL leukemia. Blood 2011; 117: 2764–2774.[http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 link to original article ][http://www.ncbi.nlm.nih.gov/pubmed?term=21190991 pubmed] | ||
| + | #Go RS, Li CY, Tefferi A, Phyliky RL(2001) Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. Blood 98:483–5 [http://bloodjournal.hematologylibrary.org/content/98/2/483.long link to original article ] [http://www.ncbi.nlm.nih.gov/pubmed?term=11435321 pubmed ] | ||
Revision as of 03:41, 18 April 2014
LGL with treatment indications
Regimen 1
Methotrexate +/- Prednisone
- Methotrexate 7.5mg/m2 to 10mg/m2 weekly po +
- Prednisone 1mg/kg po daily x one month then taper over 1 months.
stop if no response by 4 months, if response continue until progression
Supportive medications:
References
- Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95(9):1534-1541.long link to original article pubmed
- Lamy T, Loughran TP.[1] How I treat LGL leukemia. Blood 2011; 117: 2764–2774.link to original artcle pubmed
Regimen 1
Cyclophosphamide +/- Prednisone
- [[ Cyclophosphamide 50-100 mg po daily
stop if no response by 4 months, if response continue for 6-12 months ,earlier if progression. Generous po fluid intake to prevent bladder toxicity
References
- Bareau B, Rey J, Hamidou M, et al. Analysis of a French cohort of patients with large granular lymphocyte leukemia: a report on 229 cases. Haematologica 2010;95(9):1534-1541.long link to original article pubmed
- Lamy T, Loughran TP.[2] How I treat LGL leukemia. Blood 2011; 117: 2764–2774.link to original article pubmed
- Go RS, Li CY, Tefferi A, Phyliky RL(2001) Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. Blood 98:483–5 link to original article pubmed