Difference between revisions of "Dasatinib (Sprycel)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Tyrosine kinase inhibitor <ref name="insert">[http://packageinserts.bms.com/pi/pi_sprycel.pdf Dasatinib (Sprycel) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/dasatinib.pdf Dasatinib (Sprycel) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Tyrosine kinase inhibitor of BCR-ABL, the SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFR. Believed to bind to multiple conformations of the ABL kinase.<ref name="insert">[http://packageinserts.bms.com/pi/pi_sprycel.pdf Dasatinib (Sprycel) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/dasatinib.pdf Dasatinib (Sprycel) package insert (locally hosted backup)]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
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==Patient drug information== | ==Patient drug information== | ||
| − | *[http://www.chemocare.com/bio/ | + | *[http://www.chemocare.com/bio/Dasatinib.asp Dasatinib (Sprycel) patient drug information (Chemocare)]<ref>[http://www.chemocare.com/bio/Dasatinib.asp Dasatinib (Sprycel) patient drug information (Chemocare)]</ref> |
| − | *[http://www.uptodate.com/contents/ | + | *[http://www.uptodate.com/contents/dasatinib-patient-drug-information Dasatinib (Sprycel) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dasatinib-patient-drug-information Dasatinib (Sprycel) patient drug information (UpToDate)]</ref> |
==Regimens== | ==Regimens== | ||
Revision as of 03:01, 10 December 2011
General information
Class/mechanism: Tyrosine kinase inhibitor of BCR-ABL, the SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFR. Believed to bind to multiple conformations of the ABL kinase.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Dasatinib (Sprycel) patient drug information (Chemocare)[3]
- Dasatinib (Sprycel) patient drug information (UpToDate)[4]
Regimens
Standard format will be:
<acronym (if any)> <generic drug1, generic drug2, generic drug3, etc.> (disease)