Difference between revisions of "Breast cancer BRCA1 & BRCA2 genetic testing"
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Latest revision as of 16:38, 23 November 2019
Criteria for BRCA1/BRCA2 genetic testing
This is from a clinical trial protocol and is similar to, but not identical to, the NCCN breast cancer familiar risk assessment guidelines.[1] Additional resources can be found at the links below.[2][3]
- Breast cancer diagnosed ≤45 years old
- Diagnosed at age ≤50 years old with:
- first, second, or third-degree blood relative with breast cancer diagnosis ≤50 years old
- and/or epithelial ovarian or fallopian peritoneal cancer at any age
- Diagnosed at age <60 years old with a triple negative breast cancer
- Two breast primaries--that is, bilateral disease or two or more clearly separate ipsilateral primary tumors--when first breast cancer diagnosis occurred prior to age 50
- Personal history of epithelial ovarian, fallopian tube, or primary peritoneal cancer
- Diagnosed at any age with ≥2 first, second, or third-degree relatives with breast and/or epithelial ovarian, fallopian tube, or primary peritoneal cancer at any age
- First or second-degree relative of anybody known to carry a harmful BRCA1 or BRCA2 mutation
- Ashkenazi Jewish descent
- Male breast cancer
- First, second, or third-degree male relative with breast cancer