Difference between revisions of "Chlorambucil (Leukeran)"
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| + | *[http://chemocare.com/bio/chlorambucil.asp Chlorambucil (Leukeran) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/chlorambucil.asp Chlorambucil (Leukeran) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/chlorambucil-patient-drug-information Chlorambucil (Leukeran) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/chlorambucil-patient-drug-information Chlorambucil (Leukeran) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/chlorambucil-patient-drug-information Chlorambucil (Leukeran) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/chlorambucil-patient-drug-information Chlorambucil (Leukeran) patient drug information (UpToDate)]</ref> | ||
Revision as of 19:02, 5 December 2011
General information
Class/mechanism: Nitrogen mustard, alkylating agent. Interferes with DNA replication and induces apoptosis through accumulation of p53 in the cytosol and downstream activation of the apoptosis promoter Bax.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Chlorambucil (Leukeran) patient drug information (Chemocare)[3]
- Chlorambucil (Leukeran) patient drug information (UpToDate)[4]
Regimens
Standard format will be:
<acronym (if any)> <generic drug1, generic drug2, generic drug3, etc.> (disease)