Difference between revisions of "Vorinostat (Zolinza)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Histone deacetylase (HDAC) inhibitor. Vorinostat inhibits histone deacetylases HDAC1, HDAC2, and HDAC3 (Class I), as well as HDAC6 (Class II). HDACs normally catalyze removal of acetyl groups from acetylated lysine residues in histones and non-histone proteins, which helps to regulate gene expression. Inhibition of histone deacetylases results in hyperacetylation of histones and modulates gene expression by creating an open chromatin state that leads to expression of previously silenced genes. Although the mechanism of action is not fully understood, inhibiting HDACs has been observed to result in cell cycle arrest and apoptosis of cancer cells.<ref name="insert">[http://www.merck.com/product/usa/pi_circulars/z/zolinza/zolinza_pi.pdf Vorinostat (Zolinza) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/vorinostat.pdf Vorinostat (Zolinza) package insert (locally hosted backup)]</ref><ref>[http://www.zolinza.com Zolinza manufacturer's site]</ref> | + | Class/mechanism: Histone deacetylase (HDAC) inhibitor. Vorinostat inhibits histone deacetylases [http://cancer.sanger.ac.uk/cosmic/gene/overview?ln=HDAC1 HDAC1], [http://cancer.sanger.ac.uk/cosmic/gene/overview?ln=HDAC2 HDAC2], and [http://cancer.sanger.ac.uk/cosmic/gene/overview?ln=HDAC3 HDAC3] (Class I), as well as [http://cancer.sanger.ac.uk/cosmic/gene/overview?ln=HDAC6 HDAC6] (Class II). HDACs normally catalyze removal of acetyl groups from acetylated lysine residues in histones and non-histone proteins, which helps to regulate gene expression. Inhibition of histone deacetylases results in hyperacetylation of histones and modulates gene expression by creating an open chromatin state that leads to expression of previously silenced genes. Although the mechanism of action is not fully understood, inhibiting HDACs has been observed to result in cell cycle arrest and apoptosis of cancer cells.<ref name="insert">[http://www.merck.com/product/usa/pi_circulars/z/zolinza/zolinza_pi.pdf Vorinostat (Zolinza) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/vorinostat.pdf Vorinostat (Zolinza) package insert (locally hosted backup)]</ref><ref>[http://www.zolinza.com Zolinza manufacturer's site]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
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*[http://chemocare.com/bio/vorinostat.asp Vorinostat (Zolinza) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/vorinostat.asp Vorinostat (Zolinza) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/vorinostat.asp Vorinostat (Zolinza) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/vorinostat.asp Vorinostat (Zolinza) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/vorinostat-patient-drug-information Vorinostat (Zolinza) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/vorinostat-patient-drug-information Vorinostat (Zolinza) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/vorinostat-patient-drug-information Vorinostat (Zolinza) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/vorinostat-patient-drug-information Vorinostat (Zolinza) patient drug information (UpToDate)]</ref> | ||
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| + | ==History of changes in FDA indication== | ||
| + | *10/06/2006: Initial FDA approval: treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies. | ||
| + | |||
| + | ==Also known as== | ||
| + | Precise Name: Vorinostat (RXCUI 194337) | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 16:37, 25 October 2013
General information
Class/mechanism: Histone deacetylase (HDAC) inhibitor. Vorinostat inhibits histone deacetylases HDAC1, HDAC2, and HDAC3 (Class I), as well as HDAC6 (Class II). HDACs normally catalyze removal of acetyl groups from acetylated lysine residues in histones and non-histone proteins, which helps to regulate gene expression. Inhibition of histone deacetylases results in hyperacetylation of histones and modulates gene expression by creating an open chromatin state that leads to expression of previously silenced genes. Although the mechanism of action is not fully understood, inhibiting HDACs has been observed to result in cell cycle arrest and apoptosis of cancer cells.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Vorinostat (Zolinza) manufacturer's patient drug information[4]
- Vorinostat (Zolinza) patient drug information (Chemocare)[5]
- Vorinostat (Zolinza) patient drug information (UpToDate)[6]
History of changes in FDA indication
- 10/06/2006: Initial FDA approval: treatment of cutaneous manifestations in patients with cutaneous T-cell lymphoma who have progressive, persistent or recurrent disease on or following two systemic therapies.
Also known as
Precise Name: Vorinostat (RXCUI 194337)
References
- ↑ 1.0 1.1 Vorinostat (Zolinza) package insert
- ↑ Vorinostat (Zolinza) package insert (locally hosted backup)
- ↑ Zolinza manufacturer's site
- ↑ Vorinostat (Zolinza) manufacturer's patient drug information
- ↑ Vorinostat (Zolinza) patient drug information (Chemocare)
- ↑ Vorinostat (Zolinza) patient drug information (UpToDate)