Difference between revisions of "Busulfan (Myleran)"

Revision as of 18:24, 31 July 2019

General information

Class/mechanism: Bifunctional alkylating agent which produces guanine-adenine intrastrand crosslinks, inducing apoptosis.^[1]^[2]^[3]^[4]
Route: IV, PO
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Diseases for which it was used

Multiple myeloma

Patient drug information

History of changes in FDA indication

6/26/1954: Initial FDA approval

Also known as

Brand names: Busulfex, Myleran

References

[insert-1] 1.0 ^1.1 Busulfan (Myleran) package insert

[2] Busulfan (Myleran) package insert (locally hosted backup)

[3] Busulfan (Busulfex) package insert

[4] Busulfan (Busulfex) package insert (locally hosted backup)

[5] Busulfan (Myleran) patient drug information (Chemocare)

[6] Busulfan (Myleran) patient drug information (UpToDate)

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@@ Line 9: / Line 9: @@
 *[[Acute myeloid leukemia]]
 *[[Acute promyelocytic leukemia]]
-*[[Chronic lymphocytic leukemia (CLL/SLL)]]
+*[[Chronic lymphocytic leukemia]]
 *[[Chronic myelogenous leukemia]]
 *[[CNS lymphoma]]