Difference between revisions of "Amsacrine (Amsidine)"
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==Also known as== | ==Also known as== | ||
*'''Code names:''' CI-880, SN-11841 | *'''Code names:''' CI-880, SN-11841 | ||
| − | *'''Generic names:''' acridinyl anisidide, Cain's acridine | + | *'''Generic names:''' acridinyl anisidide, AMSA, Cain's acridine, m-AMSA |
*'''Brand names:''' Amekrin, Amsa P-D, Amsidine, Amsidyl, Lamasine | *'''Brand names:''' Amekrin, Amsa P-D, Amsidine, Amsidyl, Lamasine | ||
| + | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 20:52, 24 June 2019
General information
Class/mechanism: Synthetic acridine-derivate. Exact mechanism unclear; amsacrine binds to DNA by intercalation and external electrostatic binding, which inhibits DNA synthesis and causes DNA fragmentation.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
Also known as
- Code names: CI-880, SN-11841
- Generic names: acridinyl anisidide, AMSA, Cain's acridine, m-AMSA
- Brand names: Amekrin, Amsa P-D, Amsidine, Amsidyl, Lamasine