Difference between revisions of "Tagraxofusp (Elzonris)"
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m (Jwarner moved page SL-401 to Tagraxofusp (Elzonris): Generic name available) |
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==Mechanism of action== | ==Mechanism of action== | ||
− | + | From the [https://www.cancer.gov/publications/dictionaries/cancer-drug/def/dt388il3-fusion-protein-sl-401 NCI Drug Dictionary]: A recombinant protein consisting of human interleukin 3 (IL3) fused to the first 388 amino acids of diphtheria toxin [DT(388)] (DT388IL3) with potential antineoplastic activity. Upon intravenous administration, the IL3 moiety of the tagraxofusp-erzs binds to IL3 receptors on cells expressing the receptor. Subsequently, the DT(388) toxin moiety, which contains both translocation and catalytic domains, is transported across the cell membrane via endocytosis. Within the cytosol, the catalytic domain of the toxin both catalyzes the ADP-ribosylation of, and inactivates, translation elongation factor 2 (EF-2), which results in the inhibition of translation during protein synthesis. | |
− | == | + | ==Diseases for which it is used== |
− | + | *[[Blastic plasmacytoid dendritic cell neoplasm]] | |
+ | |||
+ | ==History of changes in FDA indication== | ||
+ | *12/21/2018: Initial approval for [[Blastic plasmacytoid dendritic cell neoplasm|blastic plasmacytoid dendritic cell neoplasm (BPDCN)]] in adults and in pediatric patients 2 years and older. | ||
==Also known as== | ==Also known as== | ||
*'''Code name:''' SL-401 | *'''Code name:''' SL-401 | ||
+ | *'''Generic name:''' tagraxofusp-erzs | ||
*'''Brand name:''' Elzonris | *'''Brand name:''' Elzonris | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
− | [[Category: | + | [[Category:Intravenous medications]] |
[[Category:Blastic plasmacytoid dendritic cell neoplasm medications]] | [[Category:Blastic plasmacytoid dendritic cell neoplasm medications]] | ||
− | [[Category: | + | [[Category:FDA approved in 2018]] |
Revision as of 23:15, 28 December 2018
Mechanism of action
From the NCI Drug Dictionary: A recombinant protein consisting of human interleukin 3 (IL3) fused to the first 388 amino acids of diphtheria toxin [DT(388)] (DT388IL3) with potential antineoplastic activity. Upon intravenous administration, the IL3 moiety of the tagraxofusp-erzs binds to IL3 receptors on cells expressing the receptor. Subsequently, the DT(388) toxin moiety, which contains both translocation and catalytic domains, is transported across the cell membrane via endocytosis. Within the cytosol, the catalytic domain of the toxin both catalyzes the ADP-ribosylation of, and inactivates, translation elongation factor 2 (EF-2), which results in the inhibition of translation during protein synthesis.
Diseases for which it is used
History of changes in FDA indication
- 12/21/2018: Initial approval for blastic plasmacytoid dendritic cell neoplasm (BPDCN) in adults and in pediatric patients 2 years and older.
Also known as
- Code name: SL-401
- Generic name: tagraxofusp-erzs
- Brand name: Elzonris