Difference between revisions of "Busulfan (Myleran)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
| + | *[[Acute myeloid leukemia]] | ||
*[[Acute promyelocytic leukemia]] | *[[Acute promyelocytic leukemia]] | ||
*[[Chronic lymphocytic leukemia (CLL/SLL)]] | *[[Chronic lymphocytic leukemia (CLL/SLL)]] | ||
*[[CNS lymphoma]] | *[[CNS lymphoma]] | ||
*[[Ewing's sarcoma]] | *[[Ewing's sarcoma]] | ||
| − | + | ||
| − | *[[ | + | ==Diseases for which it was used== |
| + | *[[Multiple myeloma - historical|Multiple myeloma]] | ||
==Patient drug information== | ==Patient drug information== | ||
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[[Category:Irritant chemotherapy]] | [[Category:Irritant chemotherapy]] | ||
| + | [[Category:Acute myeloid leukemia medications]] | ||
[[Category:Acute promyelocytic leukemia medications]] | [[Category:Acute promyelocytic leukemia medications]] | ||
[[Category:Chronic lymphocytic leukemia (CLL/SLL) medications]] | [[Category:Chronic lymphocytic leukemia (CLL/SLL) medications]] | ||
[[Category:CNS lymphoma medications]] | [[Category:CNS lymphoma medications]] | ||
[[Category:Ewing's sarcoma medications]] | [[Category:Ewing's sarcoma medications]] | ||
| − | [[Category: | + | [[Category:Multiple myeloma medications]] |
[[Category:FDA approved in 1954]] | [[Category:FDA approved in 1954]] | ||
Revision as of 03:38, 22 August 2018
General information
Class/mechanism: Bifunctional alkylating agent which produces guanine-adenine intrastrand crosslinks, inducing apoptosis.[1][2]
Route: IV, PO
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute myeloid leukemia
- Acute promyelocytic leukemia
- Chronic lymphocytic leukemia (CLL/SLL)
- CNS lymphoma
- Ewing's sarcoma
Diseases for which it was used
Patient drug information
- Busulfan (Myleran) patient drug information (Chemocare)[3]
- Busulfan (Myleran) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 6/26/1954: Initial FDA approval
Also known as
- Brand names: Busulfex, Myleran
References
Categories:
- Drugs
- Oral medications
- Intravenous medications
- Alkylating agents
- Irritant chemotherapy
- Acute myeloid leukemia medications
- Acute promyelocytic leukemia medications
- Chronic lymphocytic leukemia (CLL/SLL) medications
- CNS lymphoma medications
- Ewing's sarcoma medications
- Multiple myeloma medications
- FDA approved in 1954