Difference between revisions of "Romiplostim (Nplate)"
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Revision as of 19:38, 30 July 2018
General information
Class/mechanism: Thrombopoietin (TPO/cMpl) receptor agonist. Romiplostim is an Fc-peptide fusion protein (peptibody) that interacts with the TPO receptor to trigger downstream signal cascades that ultimately stimulate platelet production by promoting proliferation and differentiation of megakaryocytes from bone marrow progenitor cells.[1][2][3]
Route: SC
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Romiplostim (Nplate) package insert[1]
- Romiplostim (Nplate) patient drug information (Chemocare)[4]
- Romiplostim (Nplate) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 8/22/2008: Initial FDA approval