Difference between revisions of "Valrubicin (Valstar)"
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Revision as of 19:05, 30 July 2018
General information
Class/mechanism: Anthracycline; inhibits the incorporation of nucleosides, interferes with normal activity of DNA topoisomerase II, causing extensive chromosomal damage and cell cycle arrest in G2.[1][2][3]
Route: Intravesicular
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Valrubicin (Valstar) manufacturer's patient drug information - "Understanding Your Therapy With VALSTAR"
- Valrubicin (Valstar) patient drug information (UpToDate)[4]
Diseases for which it is used
History of changes in FDA indication
- 9/25/1998: Initial FDA approval for intravesical therapy of BCG-refractory carcinoma in situ (CIS) of the urinary bladder in patients for whom immediate cystectomy would be associated with unacceptable morbidity or mortality.