Difference between revisions of "Pixantrone (Pixuvri)"
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Revision as of 22:53, 13 June 2018
Although this drug is EMA approved as of 5/31/2013, it is not yet FDA approved.
Mechanism of action
From the NCI Drug Dictionary: The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. Route: IV
Diseases for which it is used
Also known as
- Code name: BBR 2778
- Generic name: pixantrone dimaleate
- Brand name: Pixuvri