Difference between revisions of "Copanlisib (Aliqopa)"

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From [http://www.cancer.gov/drugdictionary?CdrID=653981 NCI Drug Dictionary]: A phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations.
 
From [http://www.cancer.gov/drugdictionary?CdrID=653981 NCI Drug Dictionary]: A phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations.
  
==Preliminary data==
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==Diseases for which it is used==
===[[Follicular lymphoma]]===
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*[[Follicular lymphoma]]
# '''Abstract:''' Martin H. Dreyling, Armando Santoro, Sirpa Leppa, Judit Demeter, George Follows, Georg Lenz, Won Seog Kim, Luigina Mollica, Arnon Nagler, Colin Phipps Diong, Mariano Provencio, Don A. Stevens, David Trevarthen, Massimo Magagnoli, Lisa Cupit, Shuxin Yin, Florian Hiemeyer, Jose E. Garcia-Vargas, Barrett H. Childs, and Pier Luigi Zinzani. Copanlisib in patients with relapsed or refractory follicular lymphoma. Journal of Clinical Oncology 2017 35:15_suppl, 7535-7535 [http://ascopubs.org/doi/full/10.1200/JCO.2017.35.15_suppl.7535 link to abstract]
 
  
 
==History of changes in FDA indication==
 
==History of changes in FDA indication==
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[[Category:Kinase inhibitors]]
 
[[Category:Kinase inhibitors]]
[[Category:PI3K inhibitors]]
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[[Category:PI3K alpha inhibitors]]
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[[Category:PI3K delta inhibitors]]
  
 
[[Category:Follicular lymphoma medications]]
 
[[Category:Follicular lymphoma medications]]
  
 
[[Category:Drugs FDA approved in 2017]]
 
[[Category:Drugs FDA approved in 2017]]

Revision as of 02:41, 17 May 2018

Mechanism of action

From NCI Drug Dictionary: A phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations.

Diseases for which it is used

History of changes in FDA indication

  • 9/14/2017: Granted FDA accelerated approval "for the treatment of adult patients with relapsed follicular lymphoma who have received at least two prior systemic therapies."

Also known as

  • Code name: BAY 80-6946
  • Brand name: Aliqopa