Difference between revisions of "Tegafur and uracil (UFT)"
Warner-admin (talk | contribs) m (Text replacement - "manufacturer. Instead" to "manufacturer. Instead") |
m |
||
| Line 11: | Line 11: | ||
*[[Colon cancer]] | *[[Colon cancer]] | ||
*[[Esophageal cancer]] | *[[Esophageal cancer]] | ||
| + | *[[Rectal cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| Line 30: | Line 31: | ||
[[Category:Colon cancer medications]] | [[Category:Colon cancer medications]] | ||
[[Category:Esophageal cancer medications]] | [[Category:Esophageal cancer medications]] | ||
| + | [[Category:Rectal cancer medications]] | ||
[[Category:PMDA approved drugs]] | [[Category:PMDA approved drugs]] | ||
Revision as of 16:36, 2 January 2018
Note: this drug combination is not FDA approved but is used widely in other countries.
General information
Class/mechanism: Contains a fixed molar ratio (4:1) of uracil to tegafur. Tegafur is metabolized in vivo to Fluorouracil (5-FU), which is a pyrimidine analog antimetabolite that is metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP). Uracil helps to maintain intracellular levels of Fluorouracil (5-FU) by inhibiting its degradation.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Uracil-tegafur (UFT) patient information site[4]
- Macmillan Uracil-tegafur (UFT) patient information[5]
Also known as
- Generic name: tegafur-uracil
- Brand names: Ftorafur, Luporal, Tefudex, Ufur, Uftoral, Uracel