Difference between revisions of "Dutasteride (Avodart)"
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==General information== | ==General information== | ||
| − | Class/mechanism: 5 alpha-reductase inhibitor; inhibits conversion of testosterone to dihydrotestosterone (DHT). Competitively inhibits type 1 and 2 5 alpha-reductase isoenzymes by forming a stable enzyme complex with them.<ref name="insert">[http://us.gsk.com/products/assets/us_avodart.pdf Dutasteride (Avodart) package insert]</ref><ref>[ | + | Class/mechanism: 5 alpha-reductase inhibitor; inhibits conversion of testosterone to dihydrotestosterone (DHT). Competitively inhibits type 1 and 2 5 alpha-reductase isoenzymes by forming a stable enzyme complex with them.<ref name="insert">[http://us.gsk.com/products/assets/us_avodart.pdf Dutasteride (Avodart) package insert]</ref><ref>[[Media:Dutasteride.pdf | Dutasteride (Avodart) package insert (locally hosted backup)]]</ref><ref>[http://www.avodart.com Avodart manufacturer's website]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Prostate cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *[http://us.gsk.com/products/assets/us_avodart.pdf#page=26 Dutasteride (Avodart) package insert pages 26-29]<ref name="insert"></ref> | ||
*[http://www.uptodate.com/contents/dutasteride-patient-drug-information Dutasteride (Avodart) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dutasteride-patient-drug-information Dutasteride (Avodart) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/dutasteride-patient-drug-information Dutasteride (Avodart) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dutasteride-patient-drug-information Dutasteride (Avodart) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Antiandrogens]] | ||
| + | [[Category:5 alpha-reductase inhibitors]] | ||
| + | [[Category:Prostate cancer medications]] | ||
Revision as of 04:56, 15 October 2012
General information
Class/mechanism: 5 alpha-reductase inhibitor; inhibits conversion of testosterone to dihydrotestosterone (DHT). Competitively inhibits type 1 and 2 5 alpha-reductase isoenzymes by forming a stable enzyme complex with them.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Dutasteride (Avodart) package insert pages 26-29[1]
- Dutasteride (Avodart) patient drug information (UpToDate)[4]