Difference between revisions of "Dasatinib (Sprycel)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Tyrosine kinase inhibitor of BCR-ABL, the SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRβ. Binds to multiple conformations of the ABL kinase.<ref name="insert">[http://packageinserts.bms.com/pi/pi_sprycel.pdf Dasatinib (Sprycel) package insert]</ref><ref>[ | + | Class/mechanism: Tyrosine kinase inhibitor of BCR-ABL, the SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRβ. Binds to multiple conformations of the ABL kinase.<ref name="insert">[http://packageinserts.bms.com/pi/pi_sprycel.pdf Dasatinib (Sprycel) package insert]</ref><ref>[[Media:Dasatinib.pdf | Dasatinib (Sprycel) package insert (locally hosted backup)]]</ref><ref>[http://www.sprycel.com Sprycel maufacturer's website]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Acute lymphocytic leukemia]] | ||
| + | *[[Chronic myelogenous leukemia]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http:// | + | *[http://packageinserts.bms.com/pi/pi_sprycel.pdf#page=8 Dasatinib (Sprycel) package insert pages 8-9]<ref name="insert"></ref> |
| + | *[http://chemocare.com/chemotherapy/drug-info/dasatinib.aspx Dasatinib (Sprycel) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/dasatinib.aspx Dasatinib (Sprycel) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/dasatinib-patient-drug-information Dasatinib (Sprycel) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dasatinib-patient-drug-information Dasatinib (Sprycel) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/dasatinib-patient-drug-information Dasatinib (Sprycel) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dasatinib-patient-drug-information Dasatinib (Sprycel) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Tyrosine kinase inhibitors]] | ||
| + | [[Category:Bcr-Abl inhibitors]] | ||
| + | [[Category:Acute lymphocytic leukemia medications]] | ||
| + | [[Category:Chronic myelogenous leukemia medications]] | ||
Revision as of 17:55, 14 October 2012
Also known as BMS-354825.
General information
Class/mechanism: Tyrosine kinase inhibitor of BCR-ABL, the SRC family (SRC, LCK, YES, FYN), c-KIT, EPHA2, and PDGFRβ. Binds to multiple conformations of the ABL kinase.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Dasatinib (Sprycel) package insert pages 8-9[1]
- Dasatinib (Sprycel) patient drug information (Chemocare)[4]
- Dasatinib (Sprycel) patient drug information (UpToDate)[5]