Difference between revisions of "Dacarbazine (DTIC)"
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| + | Also known as DIC, DTIC-Dome, Imidazole Carboxamide. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Dacarbazine.pdf Dacarbazine (DTIC) package insert]</ref><ref>[ | + | Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Dacarbazine.pdf Dacarbazine (DTIC) package insert]</ref><ref>[[Media:Dacarbazine.pdf | Dacarbazine (DTIC) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[irritant]] | <br>Extravasation: [[irritant]] | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Hodgkin lymphoma]] | ||
| + | *[[Melanoma]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http:// | + | *[http://chemocare.com/chemotherapy/drug-info/dacarbazine.aspx Dacarbazine (DTIC) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/dacarbazine.aspx Dacarbazine (DTIC) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/dacarbazine-patient-drug-information Dacarbazine (DTIC) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dacarbazine-patient-drug-information Dacarbazine (DTIC) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/dacarbazine-patient-drug-information Dacarbazine (DTIC) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dacarbazine-patient-drug-information Dacarbazine (DTIC) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Irritant chemotherapy]] | ||
| + | [[Category:Alkylating agents]] | ||
| + | [[Category:DNA synthesis inhibitors]] | ||
| + | [[Category:Nucleic acid analogs]] | ||
| + | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:Melanoma medications]] | ||
Revision as of 05:26, 14 October 2012
Also known as DIC, DTIC-Dome, Imidazole Carboxamide.
General information
Class/mechanism: Alkylator, purine analog, inhibits DNA synthesis; exact mechanism unclear. Converted to the active alkylating metabolite MTIC.[1][2]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Dacarbazine (DTIC) patient drug information (Chemocare)[3]
- Dacarbazine (DTIC) patient drug information (UpToDate)[4]