Difference between revisions of "Chlorambucil (Leukeran)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Nitrogen mustard, alkylating agent. Interferes with DNA replication and induces apoptosis through accumulation of p53 in the cytosol and downstream activation of the apoptosis promoter Bax.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/010669s032lbl.pdf Chlorambucil (Leukeran) package insert]</ref><ref>[ | + | Class/mechanism: Nitrogen mustard, alkylating agent. Interferes with DNA replication and induces apoptosis through accumulation of p53 in the cytosol and downstream activation of the apoptosis promoter Bax.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/010669s032lbl.pdf Chlorambucil (Leukeran) package insert]</ref><ref>[[Media:Chlorambucil.pdf | Chlorambucil (Leukeran) package insert (locally hosted backup)]]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]] | ||
| + | *[[Hodgkin lymphoma]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/chlorambucil.aspx Chlorambucil (Leukeran) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/chlorambucil.aspx Chlorambucil (Leukeran) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/chlorambucil-patient-drug-information Chlorambucil (Leukeran) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/chlorambucil-patient-drug-information Chlorambucil (Leukeran) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/chlorambucil-patient-drug-information Chlorambucil (Leukeran) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/chlorambucil-patient-drug-information Chlorambucil (Leukeran) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Nitrogen mustards]] | ||
| + | [[Category:Alkylating agents]] | ||
| + | [[Category:Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications]] | ||
| + | [[Category:Hodgkin lymphoma medications]] | ||
Revision as of 05:34, 8 October 2012
General information
Class/mechanism: Nitrogen mustard, alkylating agent. Interferes with DNA replication and induces apoptosis through accumulation of p53 in the cytosol and downstream activation of the apoptosis promoter Bax.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Chlorambucil (Leukeran) patient drug information (Chemocare)[3]
- Chlorambucil (Leukeran) patient drug information (UpToDate)[4]