Difference between revisions of "Rucaparib (Rubraca)"
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*'''Code names:''' CO-338, AG-014699, PF-0136738 | *'''Code names:''' CO-338, AG-014699, PF-0136738 | ||
*'''Brand name:''' Rubraca | *'''Brand name:''' Rubraca | ||
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[[Category:Drug index]] | [[Category:Drug index]] | ||
Revision as of 15:19, 3 December 2017
General information
Class/mechanism: PARP inhibitor. Rucaparib inhibits activity of the poly (ADP-ribose) polymerase (PARP) enzymes--including PARP-1, PARP-2, and PARP-3--and interferes with PARP-mediated DNA repair. PARP inhibitor cytotoxicity is believed to involve formation of PARP-DNA complexes, DNA damage, apotosis, and cell death. This cytotoxicity was observed to have increased cytotoxicity in cells with mutations in BRCA1, BRCA2, and other DNA repair genes.[1][2][3][4]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 12/19/2016: FDA granted accelerated approval "for treatment of patients with deleterious BRCA mutation (germline and/or somatic) associated advanced ovarian cancer who have been treated with two or more chemotherapies."
Also known as
- Code names: CO-338, AG-014699, PF-0136738
- Brand name: Rubraca