Difference between revisions of "Aspirin"
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==General information== | ==General information== | ||
| − | Class/mechanism: Irreversible inhibitor of prostaglandin cyclooxygenase and the production of thromboxane A2 (platelet aggregation factor). Additional effects are dose-dependent and include inhibiting production of prostaglandin I2 (prostacyclin). Higher doses of aspirin have anti-inflammatory effects, in part from inhibiting cyclooxygenase.<ref name="insert">[http://www.fda.gov/ohrms/dockets/ac/03/briefing/4012B1_03_Appd%201-Professional%20Labeling.pdf Aspirin package insert]</ref><ref>[ | + | Class/mechanism: Irreversible inhibitor of prostaglandin cyclooxygenase and the production of thromboxane A2 (platelet aggregation factor). Additional effects are dose-dependent and include inhibiting production of prostaglandin I2 (prostacyclin). Higher doses of aspirin have anti-inflammatory effects, in part from inhibiting cyclooxygenase.<ref name="insert">[http://www.fda.gov/ohrms/dockets/ac/03/briefing/4012B1_03_Appd%201-Professional%20Labeling.pdf Aspirin package insert]</ref><ref>[[Media:Aspirin.pdf | Aspirin package insert (locally hosted backup)]]</ref><ref>[http://www.aspirin.com Aspirin manufacturer's website]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
Revision as of 15:44, 7 October 2012
Also known as acetylsalicylic acid, ASA, Ecotrin, Bayer Aspirin.
General information
Class/mechanism: Irreversible inhibitor of prostaglandin cyclooxygenase and the production of thromboxane A2 (platelet aggregation factor). Additional effects are dose-dependent and include inhibiting production of prostaglandin I2 (prostacyclin). Higher doses of aspirin have anti-inflammatory effects, in part from inhibiting cyclooxygenase.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]