Difference between revisions of "Amsacrine (Amsidine)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Synthetic acridine-derivate. Exact mechanism unclear; amsacrine binds to DNA by intercalation and external electrostatic binding, which inhibits DNA synthesis and causes DNA fragmentation.<ref name="insert">[http://www.nordmedica.com/fileadmin/user_upload/Pdf_filer/AMSIDINE_NL-EN.pdf Amsacrine (Amsidine) package insert]</ref><ref>[ | + | Class/mechanism: Synthetic acridine-derivate. Exact mechanism unclear; amsacrine binds to DNA by intercalation and external electrostatic binding, which inhibits DNA synthesis and causes DNA fragmentation.<ref name="insert">[http://www.nordmedica.com/fileadmin/user_upload/Pdf_filer/AMSIDINE_NL-EN.pdf Amsacrine (Amsidine) package insert]</ref><ref>[[Media:Amsacrine.pdf | Amsacrine (Amsidine) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[vesicant]] | <br>Extravasation: [[vesicant]] | ||
Revision as of 03:12, 7 October 2012
General information
Class/mechanism: Synthetic acridine-derivate. Exact mechanism unclear; amsacrine binds to DNA by intercalation and external electrostatic binding, which inhibits DNA synthesis and causes DNA fragmentation.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]