Difference between revisions of "Tivantinib (ARQ-197)"

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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.
 
==Clinical trials==
 
*[http://www.clinicaltrials.gov/ct2/show/NCT01517399 Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffein, Midazolam, and Digoxin in Cancer Subjects]
 
*[http://www.clinicaltrials.gov/ct2/show/NCT01519414 Tivantinib in Treating Patients With Metastatic Prostate Cancer]
 
*[http://www.clinicaltrials.gov/ct2/show/NCT01447914 c-Met Inhibitor ARQ 197 (Tivantinib) in Treating Patients With Relapsed Multiple Myeloma]
 
*[http://www.clinicaltrials.gov/ct2/show/NCT01575522 Tivantinib in Treating Patients With Recurrent or Metastatic Breast Cancer]
 
*[http://www.clinicaltrials.gov/ct2/show/NCT01055067 ARQ 197 for Subjects With Relapsed or Refractory Germ Cell Tumors]
 
*[http://www.clinicaltrials.gov/ct2/show/NCT01244191 ARQ 197 Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer]
 
*[http://www.clinicaltrials.gov/ct2/show/NCT01075048 ARQ 197 in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer]
 
  
 
==Patient drug information==
 
==Patient drug information==
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[[Category:Drug index]]
 
[[Category:Drug index]]
[[Category:Chemotherapy]]
 
 
[[Category:Oral medications]]
 
[[Category:Oral medications]]
  

Revision as of 14:13, 2 November 2017

General information

Class/mechanism: C-Met inhibitor. Inappropriate or constitutive activation of the receptor tyrosine kinase c-Met and its signalling pathway is implicated in many cancers, playing a role in abnormal proliferation, survival, invasion, metastasis, and angiogenesis.[1]
Route: PO
Extravasation: n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Patient drug information

No information available.

References