Difference between revisions of "BCG vaccine"
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==General information== | ==General information== | ||
Class/mechanism: Live mycobacteria which promote a local acute inflammatory and sub-acute granulomatous reaction with macrophage and leukocyte infiltration in the urothelium and lamina propria of the urinary bladder. This results in a likely T-lymphocyte dependent anti-tumor effect.<ref name="insert">[https://www.vaccineshoppecanada.com/secure/pdfs/ca/immucyst_e.pdf Bacillus Calmette-Guerin (BCG) package insert]</ref><ref>[[Media:Bacilluscalmetteguerin.pdf | Bacillus Calmette-Guerin (BCG) package insert (locally hosted backup)]]</ref> | Class/mechanism: Live mycobacteria which promote a local acute inflammatory and sub-acute granulomatous reaction with macrophage and leukocyte infiltration in the urothelium and lamina propria of the urinary bladder. This results in a likely T-lymphocyte dependent anti-tumor effect.<ref name="insert">[https://www.vaccineshoppecanada.com/secure/pdfs/ca/immucyst_e.pdf Bacillus Calmette-Guerin (BCG) package insert]</ref><ref>[[Media:Bacilluscalmetteguerin.pdf | Bacillus Calmette-Guerin (BCG) package insert (locally hosted backup)]]</ref> | ||
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*[http://chemocare.com/chemotherapy/drug-info/bcg.aspx Bacillus Calmette-Guerin (BCG) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/bcg.aspx Bacillus Calmette-Guerin (BCG) patient information (Chemocare)]</ref> | *[http://chemocare.com/chemotherapy/drug-info/bcg.aspx Bacillus Calmette-Guerin (BCG) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/bcg.aspx Bacillus Calmette-Guerin (BCG) patient information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/patient-information-bladder-cancer-treatment-non-muscle-invasive-superficial-cancer Patient information about bladder cancer treatment, including BCG (UpToDate)]<ref>[http://www.uptodate.com/contents/patient-information-bladder-cancer-treatment-non-muscle-invasive-superficial-cancer Patient information about bladder cancer treatment, including BCG (UpToDate)]</ref> | *[http://www.uptodate.com/contents/patient-information-bladder-cancer-treatment-non-muscle-invasive-superficial-cancer Patient information about bladder cancer treatment, including BCG (UpToDate)]<ref>[http://www.uptodate.com/contents/patient-information-bladder-cancer-treatment-non-muscle-invasive-superficial-cancer Patient information about bladder cancer treatment, including BCG (UpToDate)]</ref> | ||
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| + | ==Also known as== | ||
| + | *'''Generic name:''' Bacille Calmette–Guérin | ||
| + | *'''Brand names:''' TheraCys, TICE BCG | ||
==References== | ==References== | ||
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[[Category:Drug index]] | [[Category:Drug index]] | ||
| + | [[Category:Intravesicular medications]] | ||
[[Category:Immunotherapy]] | [[Category:Immunotherapy]] | ||
[[Category:T-cell activators]] | [[Category:T-cell activators]] | ||
[[Category:Bladder cancer medications]] | [[Category:Bladder cancer medications]] | ||
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| + | [[Category:FDA approved drugs]] | ||
Revision as of 02:56, 30 October 2017
General information
Class/mechanism: Live mycobacteria which promote a local acute inflammatory and sub-acute granulomatous reaction with macrophage and leukocyte infiltration in the urothelium and lamina propria of the urinary bladder. This results in a likely T-lymphocyte dependent anti-tumor effect.[1][2]
Route: Intravesicular
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Bladder cancer (intravesicular use)
Patient drug information
- Bacillus Calmette-Guerin (BCG) package insert PDF pages 22-24[1]
- Bacillus Calmette-Guerin (BCG) patient drug information (Chemocare)[3]
- Patient information about bladder cancer treatment, including BCG (UpToDate)[4]
Also known as
- Generic name: Bacille Calmette–Guérin
- Brand names: TheraCys, TICE BCG