Example orders for Cetuximab (Erbitux) in colon cancer

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Cetuximab (Erbitux)

Original references may be found at Cetuximab (Erbitux)

Example regimen #1

For cycle 1:

• Cetuximab (Erbitux) 400 mg/m2 IV over 120 minutes on day 1
  • Use non-DEHP/paclitaxel tubing.
• Cetuximab (Erbitux) 250 mg/m2 IV over 60 minutes on days 8, 15, 22
  • Use non-DEHP/paclitaxel tubing.

28-day cycle

Supportive medications:

• Acetaminophen (Tylenol) 650 mg PO 30 minutes prior to cetuximab
• Diphenhydramine (Benadryl) 50 mg IV 30 minutes prior to cetuximab

Hydration:

• 500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.

Monitoring:

• Hold if ANC <1000 or platelets <100 and notify physician.

For cycle 2 and later:

• Cetuximab (Erbitux) 250 mg/m2 IV over 60 minutes on days 1, 8, 15, 22
  • Use non-DEHP/paclitaxel tubing.

28-day cycles

Supportive medications:

• Acetaminophen (Tylenol) 650 mg PO 30 minutes prior to cetuximab
• Diphenhydramine (Benadryl) 50 mg IV 30 minutes prior to cetuximab

Hydration:

• 500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.

Monitoring:

• Hold if ANC <1000 or platelets <100 and notify physician.

Comments:

• My institution uses 28-day cycles for Cetuximab (Erbitux) regimens.