Difference between revisions of "Perifosine (KRX-0401)"
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==Mechanism of action== | ==Mechanism of action== | ||
| − | + | From the [https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=43408 NCI Drug Dictionary]: An orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. | |
==Preliminary data== | ==Preliminary data== | ||
===[[Hodgkin lymphoma]]=== | ===[[Hodgkin lymphoma]]=== | ||
| − | # Guidetti A, Carlo-Stella C, Locatelli SL, Malorni W, Mortarini R, Viviani S, Russo D, Marchianò A, Sorasio R, Dodero A, Farina L, Giordano L, Di Nicola M, Anichini A, Corradini P, Gianni AM. Phase II Study of Perifosine and Sorafenib Dual-Targeted Therapy in Patients with Relapsed or Refractory Lymphoproliferative Diseases. Clin Cancer Res. 2014 Sep 19. | + | # Guidetti A, Carlo-Stella C, Locatelli SL, Malorni W, Mortarini R, Viviani S, Russo D, Marchianò A, Sorasio R, Dodero A, Farina L, Giordano L, Di Nicola M, Anichini A, Corradini P, Gianni AM. Phase II Study of Perifosine and Sorafenib Dual-Targeted Therapy in Patients with Relapsed or Refractory Lymphoproliferative Diseases. Clin Cancer Res. 2014 Nov 15;20(22):5641-51. Epub 2014 Sep 19. [http://clincancerres.aacrjournals.org/content/20/22/5641.full link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/25239609 PubMed] |
==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
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[[Category:Drug index]] | [[Category:Drug index]] | ||
| − | [[Category: | + | [[Category:Oral medications]] |
[[Category:Kinase inhibitors]] | [[Category:Kinase inhibitors]] | ||
[[Category:AKT1 inhibitors]] | [[Category:AKT1 inhibitors]] | ||
| − | [[Category: | + | [[Category:MEK inhibitors]] |
[[Category:Investigational]] | [[Category:Investigational]] | ||
[[Category:Orphan drug]] | [[Category:Orphan drug]] | ||
Revision as of 22:27, 16 August 2017
Mechanism of action
From the NCI Drug Dictionary: An orally active alkyl-phosphocholine compound with potential antineoplastic activity. Targeting cellular membranes, perifosine modulates membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis.
Preliminary data
Hodgkin lymphoma
- Guidetti A, Carlo-Stella C, Locatelli SL, Malorni W, Mortarini R, Viviani S, Russo D, Marchianò A, Sorasio R, Dodero A, Farina L, Giordano L, Di Nicola M, Anichini A, Corradini P, Gianni AM. Phase II Study of Perifosine and Sorafenib Dual-Targeted Therapy in Patients with Relapsed or Refractory Lymphoproliferative Diseases. Clin Cancer Res. 2014 Nov 15;20(22):5641-51. Epub 2014 Sep 19. link to original article PubMed
History of changes in FDA indication
- 9/3/2009: Received FDA orphan drug designation for treatment of multiple myeloma.
- 7/9/2010: Received FDA orphan drug designation for treatment of neuroblastoma.