Difference between revisions of "Mechlorethamine (Mustargen)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Hodgkin lymphoma]] | *[[Hodgkin lymphoma]] | ||
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| + | ==Historical reference== | ||
| + | # Goodman LS, Wintrobe MM, Dameshek W, Goodman MJ, Gilman A, McLennan MT. Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. J Am Med Assoc. 1946 Sep 21;132:126-32. [http://jamanetwork.com/journals/jama/fullarticle/288442 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/20997191 PubMed] | ||
==Patient drug information== | ==Patient drug information== | ||
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==Also known as== | ==Also known as== | ||
| − | Chlormethine, Mustine | + | *'''Generic name:''' nitrogen mustard |
| + | *'''Brand names:''' Chlormethine, Mustargen, Mustine | ||
==References== | ==References== | ||
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[[Category:Drug index]] | [[Category:Drug index]] | ||
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[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
[[Category:Intracavitary medications]] | [[Category:Intracavitary medications]] | ||
Revision as of 19:52, 12 August 2017
General information
Class/mechanism: Nitrogen mustard, alkylator. Crosslinks DNA, interfering with cell replication.[1][2]
Route: IV, intracavitary
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Historical reference
- Goodman LS, Wintrobe MM, Dameshek W, Goodman MJ, Gilman A, McLennan MT. Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. J Am Med Assoc. 1946 Sep 21;132:126-32. link to original article PubMed
Patient drug information
- Mechlorethamine (Mustargen) patient drug information (Chemocare)[3]
- Mechlorethamine (Mustargen) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 3/15/1949: Initial FDA approval (This is the first chemotherapy agent ever approved)
- 2/9/2004 (only label available at Drugs @ FDA):
- "Administered intravenously, is indicated for the palliative treatment of Hodgkin's disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma."
- "Administered intrapleurally, intraperitoneally, or intrapericardially, is indicated for the palliative treatment of metastatic carcinoma resulting in effusion."
Also known as
- Generic name: nitrogen mustard
- Brand names: Chlormethine, Mustargen, Mustine