Difference between revisions of "Mycophenolate mofetil (CellCept)"
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| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information<ref name="insert"></ref> | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
==Patient drug information== | ==Patient drug information== | ||
Revision as of 06:40, 13 May 2012
General information
Class/mechanism: Immunosuppressive medication, inhibits inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil is converted in vivo to the active agent mycophenolic acid (MPA), which is a reversible, selective, and non-competitive inhibitor of inosine monophosphate dehydrogenase (IMPDH). MPA results in the inhibition of the de novo synthesis of guanosine, which T and B-cells are dependent upon for proliferation (as opposed to other cell types, which can use salvage pathways). MPA has a cytostatic effect on lymphocytes, suppresses antibody formation by B-cells, and inhibits T and B-cell proliferative response to mitogenic and allospecific stimuli. MPA also inhibits glycosylation of glycoproteins that play a role in intercellular adhesion to endothelial cells, which may suppress localization of leukocytes to areas of inflammation or graft rejection.[1][2][3]
Route: PO, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Mycophenolate mofetil (CellCept) package insert PDF pages 37-44[1]
- Mycophenolate mofetil (CellCept) patient drug information (UpToDate)[4]