Difference between revisions of "Abiraterone (Zytiga)"
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==General information== | ==General information== | ||
Class/mechanism: Antiandrogen, androgen biosynthesis inhibitor. Inhibits the 17 α-hydroxylase/C17,20-lyase (CYP17) enzyme that is required for androgen biosynthesis, leading to a decrease in androgen production in testicular, adrenal, and prostate tumor tissues.<ref name="insert">[http://www.zytiga.com/downloads/full_product_information.pdf Abiraterone (Zytiga) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/abiraterone.pdf Abiraterone (Zytiga) package insert (locally hosted backup)]</ref> | Class/mechanism: Antiandrogen, androgen biosynthesis inhibitor. Inhibits the 17 α-hydroxylase/C17,20-lyase (CYP17) enzyme that is required for androgen biosynthesis, leading to a decrease in androgen production in testicular, adrenal, and prostate tumor tissues.<ref name="insert">[http://www.zytiga.com/downloads/full_product_information.pdf Abiraterone (Zytiga) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/abiraterone.pdf Abiraterone (Zytiga) package insert (locally hosted backup)]</ref> | ||
Revision as of 18:53, 19 April 2012
General information
Class/mechanism: Antiandrogen, androgen biosynthesis inhibitor. Inhibits the 17 α-hydroxylase/C17,20-lyase (CYP17) enzyme that is required for androgen biosynthesis, leading to a decrease in androgen production in testicular, adrenal, and prostate tumor tissues.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information[1].
Patient drug information
- Abiraterone (Zytiga) package insert PDF pages 5-6[3]
- Abiraterone (Zytiga) patient drug information (UpToDate)[4]