Difference between revisions of "Carmustine (BCNU)"
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| + | Also known as bischloroethylnitrosourea, BCNU. | ||
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==General information== | ==General information== | ||
Class/mechanism: Nitrosourea, alkylates DNA and RNA, inhibits several key enzymatic processes by carbamoylation of amino acids in proteins.<ref name="insert">[http://packageinserts.bms.com/pi/pi_bicnu.pdf Carmustine (Bicnu) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/carmustine.pdf Carmustine (Bicnu) package insert (locally hosted backup)]</ref> | Class/mechanism: Nitrosourea, alkylates DNA and RNA, inhibits several key enzymatic processes by carbamoylation of amino acids in proteins.<ref name="insert">[http://packageinserts.bms.com/pi/pi_bicnu.pdf Carmustine (Bicnu) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/carmustine.pdf Carmustine (Bicnu) package insert (locally hosted backup)]</ref> | ||
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<br>Extravasation: [[vesicant]]/[[irritant]] | <br>Extravasation: [[vesicant]]/[[irritant]] | ||
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information<ref name="insert"></ref>. |
==Patient drug information== | ==Patient drug information== | ||
Revision as of 03:06, 6 April 2012
Also known as bischloroethylnitrosourea, BCNU.
General information
Class/mechanism: Nitrosourea, alkylates DNA and RNA, inhibits several key enzymatic processes by carbamoylation of amino acids in proteins.[1][2]
Route: IV
Extravasation: vesicant/irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information[1].
Patient drug information
- Carmustine (Bicnu) patient drug information (Chemocare)[3]
- Carmustine (Bicnu) patient drug information (UpToDate)[4]