Difference between revisions of "Bortezomib (Velcade)"
Jump to navigation
Jump to search
(delete regimens section) |
m |
||
| Line 1: | Line 1: | ||
| + | Also known as PS-341. | ||
| + | |||
==General information== | ==General information== | ||
Class/mechanism: Reversible inhibitor of the 26S proteasome, interfering with degradation of ubiquitinated proteins. This disrupts normal homeostatic mechansims, leading to cell death.<ref name="insert">[http://www.millennium.com/pdf/VelcadePrescribingInformation.pdf Bortezomib (Velcade) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/bortezomib.pdf Bortezomib (Velcade) package insert (locally hosted backup)]</ref> | Class/mechanism: Reversible inhibitor of the 26S proteasome, interfering with degradation of ubiquitinated proteins. This disrupts normal homeostatic mechansims, leading to cell death.<ref name="insert">[http://www.millennium.com/pdf/VelcadePrescribingInformation.pdf Bortezomib (Velcade) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/bortezomib.pdf Bortezomib (Velcade) package insert (locally hosted backup)]</ref> | ||
| Line 4: | Line 6: | ||
<br>Extravasation: [[irritant]] | <br>Extravasation: [[irritant]] | ||
| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information<ref name="insert"></ref>. |
==Patient drug information== | ==Patient drug information== | ||
Revision as of 15:10, 11 March 2012
Also known as PS-341.
General information
Class/mechanism: Reversible inhibitor of the 26S proteasome, interfering with degradation of ubiquitinated proteins. This disrupts normal homeostatic mechansims, leading to cell death.[1][2]
Route: IV, SC
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information[1].
Patient drug information
- Bortezomib (Velcade) patient drug information (Chemocare)[3]
- Bortezomib (Velcade) patient drug information (UpToDate)[4]