Difference between revisions of "Topotecan (Hycamtin)"
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(Created page with "==General information== Class/mechanism: <ref name="insert">[http://us.gsk.com/products/assets/us_hycamtin.pdf Topotecan (Hycamtin) package insert]</ref><ref>[http://hemonc.org/d...") |
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://us.gsk.com/products/assets/us_hycamtin.pdf Topotecan (Hycamtin) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/topotecan.pdf Topotecan (Hycamtin) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Topoisomerase I inhibitor. Topotecan binds to the topoisomerase I-DNA complex and prevents the religation of single strand breaks that were originally created by topoisomerase I. This leads to double strand DNA damage, which results in cell damage and cell death.<ref name="insert">[http://us.gsk.com/products/assets/us_hycamtin.pdf Topotecan (Hycamtin) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/topotecan.pdf Topotecan (Hycamtin) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: IV |
| − | <br>Extravasation: | + | <br>Extravasation: [[irritant]] |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/bio/topotecan. | + | *[http://chemocare.com/bio/topotecan.asp Topotecan (Hycamtin) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/topotecan.asp Topotecan (Hycamtin) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/topotecan-patient-drug-information Topotecan (Hycamtin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/topotecan-patient-drug-information Topotecan (Hycamtin) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/topotecan-patient-drug-information Topotecan (Hycamtin) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/topotecan-patient-drug-information Topotecan (Hycamtin) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 00:26, 25 February 2012
General information
Class/mechanism: Topoisomerase I inhibitor. Topotecan binds to the topoisomerase I-DNA complex and prevents the religation of single strand breaks that were originally created by topoisomerase I. This leads to double strand DNA damage, which results in cell damage and cell death.[1][2]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Topotecan (Hycamtin) patient drug information (Chemocare)[3]
- Topotecan (Hycamtin) patient drug information (UpToDate)[4]