Difference between revisions of "Tegafur and uracil (UFT)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Contains a fixed ratio (4:1) of uracil to tegafur. Tegafur is metabolized in vivo to [[Fluorouracil (5-FU)]], which is a pyrimidine analog antimetabolite that is metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP). Uracil helps to maintain intracellular levels of [[Fluorouracil (5-FU)]] by inhibiting its degradation.<ref name="insert">[http://hemonc.org/docs/packageinsert/uraciltegafur.pdf Uracil-tegafur (UFT) package insert]</ref><ref>[http://home.intekom.com/pharm/bm_squib/uft.html Uracil-tegafur (UFT) information]</ref><ref>[http://www.merckserono.com/en/products/oncology/colorectal_cancer/uft/uft.html UFT manufacturer's site]</ref> | + | Class/mechanism: Contains a fixed molar ratio (4:1) of uracil to tegafur. Tegafur is metabolized in vivo to [[Fluorouracil (5-FU)]], which is a pyrimidine analog antimetabolite that is metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP). Uracil helps to maintain intracellular levels of [[Fluorouracil (5-FU)]] by inhibiting its degradation.<ref name="insert">[http://hemonc.org/docs/packageinsert/uraciltegafur.pdf Uracil-tegafur (UFT) package insert]; adapted from source: [http://home.intekom.com/pharm/bm_squib/uft.html South African Electronic Package Inserts]</ref><ref>[http://home.intekom.com/pharm/bm_squib/uft.html Uracil-tegafur (UFT) information]</ref><ref>[http://www.merckserono.com/en/products/oncology/colorectal_cancer/uft/uft.html UFT manufacturer's site]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
Revision as of 21:38, 24 February 2012
Also known as Ftorafur, Tefudex, Tegafur-uracil, Ufur, and Uftoral.
General information
Class/mechanism: Contains a fixed molar ratio (4:1) of uracil to tegafur. Tegafur is metabolized in vivo to Fluorouracil (5-FU), which is a pyrimidine analog antimetabolite that is metabolized to 5-fluoro-2'-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP inhibits DNA synthesis by binding to thymidylate synthase and inhibiting production of thymidylate; FUTP interferes with RNA processing when it is mistakenly incorporated in place of uridine triphosphate (UTP). Uracil helps to maintain intracellular levels of Fluorouracil (5-FU) by inhibiting its degradation.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Uracil-tegafur (UFT) patient information site[4]
- Macmillan Uracil-tegafur (UFT) patient information[5]