Difference between revisions of "Romiplostim (Nplate)"
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(Created page with "==General information== Class/mechanism: <ref name="insert">[http://pi.amgen.com/united_states/nplate/nplate_pi_hcp_english.pdf Romiplostim (Nplate) package insert]</ref><ref>[ht...") |
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://pi.amgen.com/united_states/nplate/nplate_pi_hcp_english.pdf Romiplostim (Nplate) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/romiplostim.pdf Romiplostim (Nplate) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Thrombopoietin (TPO/cMpl) receptor agonist. Romiplostim is an Fc-peptide fusion protein (peptibody) that interacts with the TPO receptor to trigger downstream signal cascades that ultimately stimulate platelet production by promoting proliferation and differentiation of megakaryocytes from bone marrow progenitor cells.<ref name="insert">[http://pi.amgen.com/united_states/nplate/nplate_pi_hcp_english.pdf Romiplostim (Nplate) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/romiplostim.pdf Romiplostim (Nplate) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: SC |
| − | <br>Extravasation: | + | <br>Extravasation: n/a |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *[http://pi.amgen.com/united_states/nplate/nplate_pi_hcp_english.pdf#page=11 Romiplostim (Nplate) package insert PDF pages 11-14]<ref name="insert"></ref> | ||
*[http://chemocare.com/bio/romiplostim.asp Romiplostim (Nplate) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/romiplostim.asp Romiplostim (Nplate) patient drug information (Chemocare)]</ref> | *[http://chemocare.com/bio/romiplostim.asp Romiplostim (Nplate) patient drug information (Chemocare)]<ref>[http://chemocare.com/bio/romiplostim.asp Romiplostim (Nplate) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/romiplostim-patient-drug-information Romiplostim (Nplate) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/romiplostim-patient-drug-information Romiplostim (Nplate) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/romiplostim-patient-drug-information Romiplostim (Nplate) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/romiplostim-patient-drug-information Romiplostim (Nplate) patient drug information (UpToDate)]</ref> | ||
Revision as of 20:22, 24 February 2012
General information
Class/mechanism: Thrombopoietin (TPO/cMpl) receptor agonist. Romiplostim is an Fc-peptide fusion protein (peptibody) that interacts with the TPO receptor to trigger downstream signal cascades that ultimately stimulate platelet production by promoting proliferation and differentiation of megakaryocytes from bone marrow progenitor cells.[1][2]
Route: SC
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Romiplostim (Nplate) package insert PDF pages 11-14[1]
- Romiplostim (Nplate) patient drug information (Chemocare)[3]
- Romiplostim (Nplate) patient drug information (UpToDate)[4]