Ganitumab (AMG-479)
General information
Class/mechanism: Human monoclonal antibody that targets IGF-1R (insulin-like growth factor 1 receptor). IGF-1R plays a role in cell survival and cell cycle progression via the PI3K/Akt pathway. Ganitumab's mechanism of action may involve: 1. inhibition of binding of IGF-1 and IGF-2 to IGF-1R; 2. blocking the action of IGF-1R homodimers and IGF-1R/INSR (insulin receptor) hybrid receptors; 3. downregulating expession of IGF-1R.[1][2]
Route: IV
Extravasation: no information
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Patient drug information
No information available
Also known as
- Code name: AMG-479