Decitabine (Dacogen)
Also known as 5-aza-2'-deoxycytidine.
Contents |
General information
Class/mechanism: Pyrimidine/cytosine analog, DNA hypomethylating agent. Incorporates into DNA and inhibits DNA methyltransferase, causing DNA hypomethylation, which results in cellular differentiation or apoptosis.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Decitabine (Dacogen) patient drug information (Chemocare)[4]
- Brief patient counseling information can be found on pages 8-9 of the Decitabine (Dacogen) package insert[1]
- Decitabine (Dacogen) patient drug information (UpToDate)[5]
