Trimethoprim/Sulfamethoxazole (Bactrim DS)

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General information

Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.[1][2]
Route: PO, IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

Also known as

Synonyms
Abacin Abactrim Abatrim Abditri Abetrim Actrim Adco-CO-Trimoxazole Aditrim
Adrenol Adtrim Aksotran Albrotran Albutrim Alcorim-F Alcot Allibac
Altrim Amazole Amoxazol Amtran Amtril Andoprim Anitrim Anprim
Antibac Antrim Antrimox Apcetrim APO-Bactotrim APO-Sulfatrim DS APO Sulfatrim Apotrinelax
Aptrim Aratran Ascotran Aspen Cotrimazole Assepium Atomexin Avlotrin B.S.
BAC-Sulfitrin Bacfar Bacidal Bacin Bacitran Bacmetrin Bacoprim Bacotrin
Bacprotin Bacris Bacsulfaprin Bacsultrim Bactar Bactazol Bactekod Bactelan
Bacteracin Bacterial Bacteric Bacteriof.klebs PN Bacterol Bacticel Bactide Bactifor
Bactigram Bactille-TS Bactipront Bactiseptol Bactiver Bactoprim Bactoprim Combi Bactoreduct
Bactosain Bactostab Bactramin Bactramin C Bactricid Bactricida Bactricin Bactrilac
Bactrim Bactrim-F Bactrim DS Bactrimel Bactrim Forte Bactrim Paediatric Bactrim Perfusione Bactrim Roche
Bactrin Bactrisan Bactrium DS Bactrizole Bactron Bactronil Bactropin Bacxal
Baczin Baczole Baklinger Baktar Bakton Baktrisid DS Balkatrin Balkatrine
Balkatrin Forte Bantizol Basatin Baserin Batrox Baxolex Belfactrin Belfactrin F
Bencole Benectrin Benectrin F Berlocid Bestofens Bethaprim Bethaprim DS Bibakrim
Bicotrim Bimatrim Biogenerics Cotrimoxazole Bioprim Biosulten Biotran Biotrim Biotrin
Biprim Biseptin Biseptol Biseptrim Bismoral Bisultrim Bitrim Blexon
Boie Cotrimoxazole Boschtrim Brifeseptol Broncoflam Brongenit BS Canprim Caretran
Centrim Chemitrim Chemix Chemizol Chemoprim Chemotran Chemotrim Chemotrin
Chemozole Chromo-Z Cidaprim Cipaprim Ciplin Ciplin DS Citrim Cladon
Clinitran Clonea Clotrizol CM Trimeth S / Meth CO-Sultrin CO-Tasian CO-Traisole 480 CO-Trim-Tablinen
CO-Trimazole CO-Trimed CO-Trimed D / S CO-Trimoxa CO-Trimoxazol A CO-Trimoxazole DS CO-Trimoxazole Pharmaniaga CO-Trimoxazol FLX
Cobact Cobal ST Cocydal Cofatrim Colitran Colizole Colotrim Comax
Comazole Comazole N Combact Combi-Methoxan Comixco Comox Comoxol Contrimoxazole
Coprim Coprime Cosat Cosig Costazole Cosulf Cotoram Cotran
Cotrazen Cotrexel Cotri Cotribase Cotribene Cotribid Cotril Cotril Forte
Cotrilin Cotrim Cotrim-CT Cotrim-Puren Cotrim-Sandoz Cotrim ABZ Cotrimax Cotrimaxazol
Cotrimaxazole Cotrim Diolan Cotrim E Cotrimel Cotrim Forte Cotrim Forte EU RHO Cotrim Hefa Cotrimhexal
Cotrim Holsten Saft Cotrimol Cotrimox Cotrimoxazol Cotrimoxazol-Cophar Cotrimoxazol AL Cotrimoxazole CO Trimoxazole COX
CO Trimoxazole KNT Cotrimoxazole Ratiopharm Cotrimoxazole RPG Cotrimoxazol Genericon Pharma Cotrimoxazol Richet Forte Cotrimoxazol Vatch Cotrimoxin Cotrimox Wolff
Cotrimstada Cotripharm Cotrisul Cotrixyl-L Cotrizol Cotrizol-G Cotrizole Cots
Cozol Cozole Creptrim Curaprim Daiphen Decatrim Deotrim Dertrin
Dhatrin Dino-BAC Diseptyl Diseptyl Forte DLI Cotrimoxazole Doctrim Dosatran Drilozole
Drossul Droxol Drylin Dubac Dumotrim Duobact Duobiocin Duoctrin
DUO Septol Duratrimet Dutran Dvaseptol Dynaprim Ectaprim Ectaprim F Ectrin
Editrim Eduprim Eliprim Eroprim Erotrim Erphatrim Esbesul Escoprim
Espectrin Espectroprima Ethitrim Eurotrim Eusaprim Eutrim Exazol Fabubac
Fakzol Falprim Fameprim Fectrim Fedimed Fisat Flatran Flocot
Forcrim Forteprim G-Cotrimoxazole Gamactrin Gatrima Genoctrin Genoxzole Gentrim
Genzaprim Getrim Globaxol Gobens Trim Graprima Groseptol Gunametrim Hatrix
Helm Cotrimoxazole Helveprim Herixina Hexaprim Hicot Hufacid Huma-Trimel Ibtrim
Imcotran Imexim Inatrim Infatrim Infectran Infectrim Infectrin Infectrin F
Infesin Intrafort Introcin Irgagen Isoprim Isotrim Japtrim Jasotrim
Jenamoxazol Jestrim Justeprim K.B.famate Kaftrim Kathrex Katrim Kaytran
Kemocid Kemoprim Kentricid Kepinol Kindoprim KO-Kure Kombina Kotazol
Kotrimoksazol Krobactrol L-Trim Lacreozole Lafayette Cotrimoxazole Lagatrim Lapikot Laratrim
Larprim Lastrim Leotrim Leprim Lescot Letus Lictora Lifactrin
Lifzol Lisaprin Litrim Lobact Longasal Lupectrin Lusaprim Lykaprim
M-Moxa M-Trim Macprim Macromed Mactran Madroxin Maktrim Martiprim
Maxaprim Maxiprim Maxitrin Maxitrin-C Maxol Maxtrim Maxzol Mazatrim
Mebryn Medcotrim Medic AID Cotrimoxazole Mediprim Meditran Meditrim Medtrim Megabroncoflam
Megaset Megatrim Meprim Meprotrin Merck-CO-Trimoxazol Methoprim Methotrin Metoprim
Metoprin Metoxiprim Metrim Metrim-F Metrim-H Metxaprim Mexaprim Mexazole
Mezenol Micinovo Micogyl Micro-Cotrimoxazol Microbid Microbid DS Microcetim Micro CO-Trimoxazole
Microdyn Microsupos Amigdalar Microtrim Mikotrim Mikrosid Miratrim Moly Mortin
Moxadden Moxalas Moxatrim Moxzole Mukadryl Myctrim Naftran Napatrim
Navatrim Necorzole Neoset Neotrim Netocur Neuroprim Nicotrim Nilium
Nodilon Nopil Norisep Nortrim Nortrime Notrim Notrime Novactil
Novidrine Novotrimel Novotrimel DS Novotrimox Novotrim Plus Novozole NU-Cotrimox NU-Cotrimox DS
Nucotrim Nufaprim NUO DE FEI Nuruzole Octil-S Octran Octrim Oecotrim
Okatrim Omegtrim Omnatrim Omsat Onetrim Oradin Orbak Orgastran
Oribact Ormoprim Ostrin Forte Otrim Ottoprim Oxaprim Pakzole Pantrim
Patrim Pehatrim Penetrin Pentrin Penzole Pharex CO-Trimoxazole Pharmatrim Pharmazol
Phartex Pisatrina Plurisul Polibatrin Politrim Polytran Pribac Primadex
Primasul Primasulf Primatrim Primavon Primazol Primazole Primazol Sterkar Primotren
Primox Primsulfon Primzole Protrin Protrin DF Pulkrin Purbac Q-MED CO-Trimoxazole
Qiftrim Qiftrin Quimio-PED Quisulyn Rancotrim Rasat Raseptol Ratrim
Regtin Rematrim Renatrim Resprim Resprim M Retrim Rexaprim Ribatrim
Rimazole Rimezone Riva-SEP DS Rivoprim Rizol Rolab-CO-Trimoxazole Rolprim Roubac
Roxtrim Roytrin Salgatran Saltrim Sanprima Saptrim Satrim Sbpa Trimeth Smeth
Scribcin Seematrim Seftrim Selectrin Semozol Sepiran Sepmax Septabid
Septabid-2 Septazol Septazole Septerin Septinix Septiolan Septocid R + Septoprin
Septra Septra DS Septran Septrin-S Septrin Paediatric Servitrim Servitrim-F Sigaprim
Sigatrim Silpin Siltran Sinatrim Sinersul Sinotrim Sisoprim Sistrim
Sitrim Skytrin Smartrim SMX / TMP SMZ ( CO ) SMZ-TMP SMZ-TMP DS Soltrim
Soltrim F Soptrim Sosetran Spectrem Spectrim Stan Stopan Strim
Suftrex Sulbacta Sulfa 100 + Trim 20 Sulfa 200 + Trima 40 Sulfa 400 + Trima 80 Sulfa 800 + Trima 160 Sulfagrand Sulfamer
Sulfamet Sulfamethoprim Sulfamethoxazole and Trimethoprim Sulfamethoxazole C Sulfamethoxazole / Trimethoprim Sulfamethoxazole with Trimethoprim Sulfametosazol CON Trimetoprim Sulfametoxazol
Sulfametoxazol / Trimetoprim Sulfametoxazol MED Trimetoprim Sulfametoxazol MED Trimetoprim SAD Sulfametoxazol + Trimetoprima Sulfametoxazol Y Trimetoprima MF Sulfaprim Sulfarim Sulfatalpin
Sulfaton Sulfatrim Sulfatrim DS Sulfatropim Sulfawal-T Sulfinam Sulfinam S Sulfoid Trimetho
Sulfometh Sulfonamide Sulfort Sulfotrim Sulfotrimin Sulfotrim PED Sulftran Sulgotri
Sulotrim Sulotrim Forte Sulphaprim Sulphathoprim Sulphatran Sulphatrim Sulphax Sulphytrim Forte
Sulphytrim Junior Sulprim Sulprimed Sultase Sulthrim Sulthrim-F Sultiprim Sultorim
Sultra Sultrex Sultrim Sultrima Sultrimmix Sultrivon-F Sultropim Sumetoprim
Sumetrolim Sumetrolin Sumitran Suntrim Supim Supracombin Suprasulf Suprex
Supribac Supribac F Suprim Suprimass Suprin Suptrex Suptrim Sutaprim
Sutrim Sutrisan Suxprim Syltrifil Synac Synastat Synbac Synco-Smzt
Syndal Synermed Synerzole Synetra Synotrim Syntoprim System T.S
Tabrol Tagremin Teof Terasulf Terbosulfa Teutrin Theraprim Therasept
Theratrim Thoprim Thriazol Thriazol-S TMP-SMX TMS Torrid Tprim
Trelibec Trib Trib DS Tricban Tricomox Tricot Trifides Triforam
Trihexal Trim Trim-S Trim. Comp. Trima Trimaxazole Trimel Trimephar
Trimeran Trimerazin Trimeril Trimesol Trimesul Trimesulf Trimesulf-F Trimeta
Trimethoprim Comp. Trimethoprim Sulfa Trimethoprim Sulfamethoxazole Trimethox Trimetoger Trimetop Duplo Trimetoprim-Sulfa GEA Trimetoprima
Trimetoprima CON Sulfametoxazol Trimetoprim + Sulfametoxazol Trimetoprim Sulfa Trimetoprim Sulfa Genfar Trimetoprim Sulfametoxazol Trimetoprim Sulfametoxazol MK Trimetoprim with Sulfametoxazol Trimetoprin Sulfa
Trimetotal Trimetox Trimetrin Trimetsol Trimexasol Trimexazol Trimexazole Trimexole-F
Trimezol Trimezole Trimfasul Trimidar M Triminex Trimocom Trimoks Trimosul
Trimosulfa Trimoxavin Trimoxazol Trimoxazole-BC Trimoxin Trimoxis Trimoxsul Trimozol
Trimsul Trimzol Triphimox Tripur Trisep Trisfides Trisolak Forte Trisolvat
Trisul Trisulcom Trisulfa Trisulfa F Trisulfose Trisuprim Trisural Tritenk
Tritenk Forte Tritosul Tritosul F Trixazol Trixazol Fort Trixzol Trizole Tryseptolum
TW Trimeth S / Meth Tytrim U-Prin Ulfaprim Ultrasept Ultrazole Ultrim Unitran
Uprina Urethrax Urodown Uroplus DS Urtium Utrin Versatrim Virin
Weiditrin Wiatrim Wiltran Wypal X-Trim XA-Zole Xazotrim Xepaprim
Xerazole Xeroprim Yekaprim Zactron Zamboprim Zantran Zaxol Zecatrim
Zeptra Zerrprim Zolebid Zolmed Zoltrijem Zoltrim Zultrop

References

  1. 1.0 1.1 Trimethoprim/Sulfamethoxazole (Bactrim DS) package insert
  2. Trimethoprim/Sulfamethoxazole (Bactrim DS) package insert (locally hosted backup)
  3. Trimethoprim/Sulfamethoxazole (Bactrim DS) patient drug information (UpToDate)