Trimethoprim/Sulfamethoxazole (Bactrim DS)

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General information

Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.[1][2]
Route: PO, IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

Also known as

  • Generic names: cotrimazole, cotrimoxazole, co-trimoxazole, SMX / TMP, SMZ ( CO ), SMZ-TMP, SMZ-TMP DS, TMP-SMX, TMS
  • Brand names:
Synonyms
Abacin Abactrim Abatrim Abditri Abetrim Actrim Aditrim Adrenol
Adtrim Aksotran Albrotran Albutrim Alcorim-F Alcot Allibac Altrim
Amazole Amoxazol Amtran Amtril Andoprim Anitrim Anprim Antibac
Antrim Antrimox Apcetrim APO-Bactotrim APO Sulfatrim Apotrinelax Aptrim Aratran
Ascotran Aspen Assepium Atomexin Avlotrin B.S. BAC-Sulfitrin Bacfar
Bacidal Bacin Bacitran Bacmetrin Bacoprim Bacotrin Bacprotin Bacris
Bacsulfaprin Bacsultrim Bactar Bactazol Bactekod Bactelan Bacteracin Bacterial
Bacteric Bacteriof.klebs PN Bacterol Bacticel Bactide Bactifor Bactigram Bactille-TS
Bactipront Bactiseptol Bactiver Bactoprim Bactoreduct Bactosain Bactostab Bactramin
Bactricid Bactricida Bactricin Bactrilac Bactrim Bactrimel Bactrin Bactrisan
Bactrium DS Bactrizole Bactron Bactronil Bactropin Bacxal Baczin Baczole
Baklinger Baktar Bakton Baktrisid DS Balkatrin Balkatrine Bantizol Basatin
Baserin Batrox Baxolex Belfactrin Bencole Benectrin Berlocid Bestofens
Bethaprim Bibakrim Bicotrim Bimatrim Bioprim Biosulten Biotran Biotrim
Biotrin Biprim Biseptin Biseptol Biseptrim Bismoral Bisultrim Bitrim
Blexon Boschtrim Brifeseptol Broncoflam Brongenit BS Canprim Caretran
Centrim Chemitrim Chemix Chemizol Chemoprim Chemotran Chemotrim Chemotrin
Chemozole Chromo-Z Cidaprim Cipaprim Ciplin Citrim Cladon Clinitran
Clonea Clotrizol CO-Sultrin CO-Tasian CO-Traisole 480 CO-Trim-Tablinen CO-Trimazole CO-Trimed
CO-Trimoxa CO-Trimoxazol Cobact Cobal ST Cocydal Cofatrim Colitran Colizole
Colotrim Comax Comazole Combact Combi-Methoxan Comixco Comox Comoxol
Contrimoxazole Coprim Coprime Cosat Cosig Costazole Cosulf Cotoram
Cotran Cotrazen Cotrexel Cotri Cotribase Cotribene Cotribid Cotril
Cotrilin Cotrim Cotrimax Cotrimaxazol Cotrimaxazole Cotrimel Cotrimhexal Cotrimol
Cotrimox Cotrimoxazol Cotrimoxin Cotrimstada Cotripharm Cotrisul Cotrixyl-L Cotrizol
Cotrizole Cots Cozol Cozole Creptrim Curaprim Daiphen Decatrim
Deotrim Dertrin Dhatrin Dino-BAC Diseptyl Doctrim Dosatran Drilozole
Drossul Droxol Drylin Dubac Dumotrim Duobact Duobiocin Duoctrin
DUO Septol Duratrimet Dutran Dvaseptol Dynaprim Ectaprim Ectrin Editrim
Eduprim Eliprim Eroprim Erotrim Erphatrim Esbesul Escoprim Espectrin
Espectroprima Ethitrim Eurotrim Eusaprim Eutrim Exazol Fabubac Fakzol
Falprim Fameprim Fectrim Fedimed Fisat Flatran Flocot Forcrim
Forteprim Gamactrin Gatrima Genoctrin Genoxzole Gentrim Genzaprim Getrim
Globaxol Gobens Trim Graprima Groseptol Gunametrim Hatrix Helveprim Herixina
Hexaprim Hicot Hufacid Huma-Trimel Ibtrim Imcotran Imexim Inatrim
Infatrim Infectran Infectrim Infectrin Infesin Intrafort Introcin Irgagen
Isoprim Isotrim Japtrim Jasotrim Jenamoxazol Jestrim Justeprim K.B.famate
Kaftrim Kathrex Katrim Kaytran Kemocid Kemoprim Kentricid Kepinol
Kindoprim KO-Kure Kombina Kotazol Kotrimoksazol Krobactrol L-Trim Lacreozole
Lagatrim Lapikot Laratrim Larprim Lastrim Leotrim Leprim Lescot
Letus Lictora Lifactrin Lifzol Lisaprin Litrim Lobact Longasal
Lupectrin Lusaprim Lykaprim M-Moxa M-Trim Macprim Macromed Mactran
Madroxin Maktrim Martiprim Maxaprim Maxiprim Maxitrin Maxol Maxtrim
Maxzol Mazatrim Mebryn Medcotrim Mediprim Meditran Meditrim Medtrim
Megabroncoflam Megaset Megatrim Meprim Meprotrin Methoprim Methotrin Metoprim
Metoprin Metoxiprim Metrim Metxaprim Mexaprim Mexazole Mezenol Micinovo
Micogyl Microbid Microcetim Microdyn Microsupos Amigdalar Microtrim Mikotrim Mikrosid
Miratrim Moly Mortin Moxadden Moxalas Moxatrim Moxzole Mukadryl
Myctrim Naftran Napatrim Navatrim Necorzole Neoset Neotrim Netocur
Neuroprim Nicotrim Nilium Nodilon Nopil Norisep Nortrim Nortrime
Notrim Notrime Novactil Novidrine Novotrimel Novotrimox Novotrim Plus Novozole
Nucotrim Nufaprim Nuruzole Octil-S Octran Octrim Oecotrim Okatrim
Omegtrim Omnatrim Omsat Onetrim Oradin Orbak Orgastran Oribact
Ormoprim Ostrin Forte Otrim Ottoprim Oxaprim Pakzole Pantrim Patrim
Pehatrim Penetrin Pentrin Penzole Pharmatrim Pharmazol Phartex Pisatrina
Plurisul Polibatrin Politrim Polytran Pribac Primadex Primasul Primasulf
Primatrim Primavon Primazol Primazole Primotren Primox Primsulfon Primzole
Protrin Pulkrin Purbac Qiftrim Qiftrin Quimio-PED Quisulyn Rancotrim
Rasat Raseptol Ratrim Regtin Rematrim Renatrim Resprim Retrim
Rexaprim Ribatrim Rimazole Rimezone Rivoprim Rizol Rolprim Roubac
Roxtrim Roytrin Salgatran Saltrim Sanprima Saptrim Satrim Sbpa Trimeth Smeth
Scribcin Seematrim Seftrim Selectrin Semozol Sepiran Sepmax Septabid
Septazol Septazole Septerin Septinix Septiolan Septocid R + Septoprin Septra
Septran Septrin-S Septrin Paediatric Servitrim Sigaprim Sigatrim Silpin Siltran
Sinatrim Sinersul Sinotrim Sisoprim Sistrim Sitrim Skytrin Smartrim
Soltrim Soptrim Sosetran Spectrem Spectrim Stan Stopan Strim
Suftrex Sulbacta Sulfagrand Sulfamer Sulfamet Sulfamethoprim Sulfametoxazol Sulfaprim
Sulfarim Sulfatalpin Sulfaton Sulfatrim Sulfatropim Sulfawal-T Sulfinam Sulfoid Trimetho
Sulfometh Sulfonamide Sulfort Sulfotrim Sulfotrimin Sulftran Sulgotri Sulotrim
Sulphaprim Sulphathoprim Sulphatran Sulphatrim Sulphax Sulphytrim Forte Sulprim Sulprimed
Sultase Sulthrim Sultiprim Sultorim Sultra Sultrex Sultrim Sultrima
Sultrimmix Sultrivon-F Sultropim Sumetoprim Sumetrolim Sumetrolin Sumitran Suntrim
Supim Supracombin Suprasulf Suprex Supribac Suprim Suprimass Suprin
Suptrex Suptrim Sutaprim Sutrim Sutrisan Suxprim Syltrifil Synac
Synastat Synbac Synco-Smzt Syndal Synermed Synerzole Synetra Synotrim
Syntoprim System Tabrol Tagremin Teof Terasulf Terbosulfa Teutrin
Theraprim Therasept Theratrim Thoprim Thriazol Torrid Tprim Trelibec
Trib Tricban Tricomox Tricot Trifides Triforam Trihexal Trim
Trima Trimaxazole Trimel Trimephar Trimeran Trimerazin Trimeril Trimesol
Trimesul Trimesulf Trimeta Trimethox Trimetoger Trimetop Duplo Trimetotal Trimetox
Trimetrin Trimetsol Trimexasol Trimexazol Trimexazole Trimexole-F Trimezol Trimezole
Trimfasul Trimidar M Triminex Trimocom Trimoks Trimosul Trimosulfa Trimoxavin
Trimoxazol Trimoxazole-BC Trimoxin Trimoxis Trimoxsul Trimozol Trimsul Trimzol
Triphimox Tripur Trisep Trisfides Trisolak Forte Trisolvat Trisul Trisulcom
Trisulfa Trisulfose Trisuprim Trisural Tritenk Tritosul Trixazol Trixzol
Trizole Tryseptolum Tytrim U-Prin Ulfaprim Ultrasept Ultrazole Ultrim
Unitran Uprina Urethrax Urodown Uroplus DS Urtium Utrin Versatrim
Virin Weiditrin Wiatrim Wiltran Wypal X-Trim XA-Zole Xazotrim
Xepaprim Xerazole Xeroprim Yekaprim Zactron Zamboprim Zantran Zaxol
Zecatrim Zeptra Zerrprim Zolebid Zolmed Zoltrijem Zoltrim Zultrop

References