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Folinic acid (Leucovorin)

86 bytes added, 20:07, 21 February 2012
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==General information==
Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of [[Fluorouracil (5-FU)]] by inhibiting thymidylate synthase.<ref name="insert">[http://patient.cancerconsultants.com/druginserts/Leucovorin_inj.pdf Folinic acid (Leucovorin) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/folinicacid.pdf Folinic acid (Leucovorin) package insert (locally hosted backup)]</ref>
<br>Route: PO, IM, IV
<br>Extravasation: no information
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