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Hereditary hemorrhagic telangiectasia

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| style="background-color:#d73027" |Inferior frequency of epistaxis
|-
|[https://wwwdoi.sciencedirectorg/10.com1016/science/article/pii/S0049384814003387 j.thromres.2014.06.012 Geisthoff et al. 2014 (TAHHT)]
| style="background-color:#1a9851" |Phase III (C)
|[[#Tranexamic_acid_monotherapy|Tranexamic acid]]
===References===
# Yaniv E, Preis M, Hadar T, Shvero J, Haddad M. Antiestrogen therapy for hereditary hemorrhagic telangiectasia: a double-blind placebo-controlled clinical trial. Laryngoscope. 2009 Feb;119(2):284-8. [https://onlinelibrary.wiley.com/doi/full/10.1002/lary.20065 link to original article] [https://pubmed.ncbi.nlm.nih.gov/19160429 PubMed]
# '''TAHHT:''' Geisthoff UW, Seyfert UT, Kübler M, Bieg B, Plinkert PK, König J. Treatment of epistaxis in hereditary hemorrhagic telangiectasia with tranexamic acid - a double-blind placebo-controlled cross-over phase IIIB study. Thromb Res. 2014 Sep;134(3):565-71. Epub 2014 Jun 16. [https://wwwdoi.sciencedirectorg/10.com1016/science/article/pii/S0049384814003387 j.thromres.2014.06.012 link to SD original article] [https://pubmed.ncbi.nlm.nih.gov/25005464 PubMed]
# '''ATERO:''' Gaillard S, Dupuis-Girod S, Boutitie F, Rivière S, Morinière S, Hatron PY, Manfredi G, Kaminsky P, Capitaine AL, Roy P, Gueyffier F, Plauchu H; ATERO Study Group. Tranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease. J Thromb Haemost. 2014 Sep;12(9):1494-502. Epub 2014 Jul 29. [https://onlinelibrary.wiley.com/doi/full/10.1111/jth.12654 link to original article] [https://pubmed.ncbi.nlm.nih.gov/25040799 PubMed]
# '''ALEGORI:''' Dupuis-Girod S, Ambrun A, Decullier E, Fargeton AE, Roux A, Bréant V, Colombet B, Rivière S, Cartier C, Lacombe P, Chinet T, Blivet S, Blondel JH, Gilbert-Dussardier B, Dufour X, Michel J, Harle JR, Dessi P, Faure F. Effect of Bevacizumab Nasal Spray on Epistaxis Duration in Hereditary Hemorrhagic Telangectasia: A Randomized Clinical Trial. JAMA. 2016 Sep 6;316(9):934-42. [https://jamanetwork.com/journals/jama/fullarticle/2547754 link to original article] [https://pubmed.ncbi.nlm.nih.gov/27599328 PubMed]
!style="width: 25%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]]
|-
|[https://wwwdoi.sciencedirectorg/10.com1016/science/article/pii/S0049384814003387 j.thromres.2014.06.012 Geisthoff et al. 2014 (TAHHT)]
| style="background-color:#1a9851" |Phase III (E-esc)
|[[#Placebo|Placebo]]
===References===
# '''TAHHT:''' Geisthoff UW, Seyfert UT, Kübler M, Bieg B, Plinkert PK, König J. Treatment of epistaxis in hereditary hemorrhagic telangiectasia with tranexamic acid - a double-blind placebo-controlled cross-over phase IIIB study. Thromb Res. 2014 Sep;134(3):565-71. Epub 2014 Jun 16. [https://wwwdoi.sciencedirectorg/10.com1016/science/article/pii/S0049384814003387 j.thromres.2014.06.012 link to SD original article] [https://pubmed.ncbi.nlm.nih.gov/25005464 PubMed]
# '''ATERO:''' Gaillard S, Dupuis-Girod S, Boutitie F, Rivière S, Morinière S, Hatron PY, Manfredi G, Kaminsky P, Capitaine AL, Roy P, Gueyffier F, Plauchu H; ATERO Study Group. Tranexamic acid for epistaxis in hereditary hemorrhagic telangiectasia patients: a European cross-over controlled trial in a rare disease. J Thromb Haemost. 2014 Sep;12(9):1494-502. Epub 2014 Jul 29. [https://onlinelibrary.wiley.com/doi/full/10.1111/jth.12654 link to original article] [https://pubmed.ncbi.nlm.nih.gov/25040799 PubMed]
# '''NOSE:''' Whitehead KJ, Sautter NB, McWilliams JP, Chakinala MM, Merlo CA, Johnson MH, James M, Everett EM, Clancy MS, Faughnan ME, Oh SP, Olitsky SE, Pyeritz RE, Gossage JR. Effect of Topical Intranasal Therapy on Epistaxis Frequency in Patients With Hereditary Hemorrhagic Telangiectasia: A Randomized Clinical Trial. JAMA. 2016 Sep 6;316(9):943-51. [https://jamanetwork.com/journals/jama/fullarticle/2547755 link to original article] [https://pubmed.ncbi.nlm.nih.gov/27599329 PubMed]
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