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===Regimen {{#subobject:4c9de2|Variant=1}}===
{| class="wikitable" style="width: 100%; text-align:center;"
!style="width: 2520%"|Study!style="width: 2520%"|Years of enrollment!style="width: 20%"|[[Levels_of_Evidence#Evidence|Evidence]]!style="width: 2520%"|Comparator!style="width: 2520%"|[[Levels_of_Evidence#Comparative_efficacy|Comparative Efficacy]]
|-
|[https://doi.org/10.1200/JCO.1996.14.3.911 Veerman et al. 1996 (DCOG ALL-VI)]
|{{#subobject:xx|ToDo=1}}
| style="background-color:#91cf61" |Non-randomized
| style="background-color:#d3d3d3" |
|-
|[http://www.bloodjournal.org/content/101/10/3809.long Bostrom et al. 2003 (CCG-1922)]
|{{#subobject:xx|ToDo=1}}
|style="background-color:#1a9851"|Phase III (E-switch-ic)
|[[#L-Asparaginase.2C_Vincristine.2C_Prednisone|L-asparaginase, Vincristine, Prednisone]]
|-
|[https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2005.05509.x/full Mitchell et al. 2005 (UK MRC ALL97)]
|{{#subobject:xx|ToDo=1}}
|style="background-color:#1a9851"|Phase III (E-switch-ic)
|[[#L-Asparaginase.2C_Vincristine.2C_Prednisolone|L-asparaginase, Vincristine, Prednisolone]]
|style="background-color:#1a9850"|Superior EFS
|-
|[https://wwwdoi.sciencedirectorg/10.com1016/science/article/pii/S1470204509702281 s1470-2045(09)70228-1 Veerman et al. 2009 (DCOG ALL-9)]|1997-2004
| style="background-color:#91cf61" |Non-randomized
| style="background-color:#d3d3d3" |
# '''UK MRC ALL97:''' Mitchell CD, Richards SM, Kinsey SE, Lilleyman J, Vora A, Eden TO; Medical Research Council Childhood Leukaemia Working Party. Benefit of dexamethasone compared with prednisolone for childhood acute lymphoblastic leukaemia: results of the UK Medical Research Council ALL97 randomized trial. Br J Haematol. 2005 Jun;129(6):734-45. [https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2005.05509.x/full link to original article] [https://pubmed.ncbi.nlm.nih.gov/15952999 PubMed]
## '''Update:''' Vora A, Mitchell CD, Lennard L, Eden TO, Kinsey SE, Lilleyman J, Richards SM; Medical Research Council; National Cancer Research Network Childhood Leukaemia Working Party. Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. Lancet. 2006 Oct 14;368(9544):1339-48. [https://www.thelancet.com/journals/lancet/article/PIIS0140673606695585/fulltext link to original article] [https://pubmed.ncbi.nlm.nih.gov/17046466 PubMed]
# '''DCOG ALL-9:''' Veerman AJ, Kamps WA, van den Berg H, van den Berg E, Bökkerink JP, Bruin MC, van den Heuvel-Eibrink MM, Korbijn CM, Korthof ET, van der Pal K, Stijnen T, van Weel Sipman MH, van Weerden JF, van Wering ER, van der Does-van den Berg A; Dutch Childhood Oncology Group. Dexamethasone-based therapy for childhood acute lymphoblastic leukaemia: results of the prospective Dutch Childhood Oncology Group (DCOG) protocol ALL-9 (1997-2004). Lancet Oncol. 2009 Oct;10(10):957-66. Epub 2009 Sep 9. [https://wwwdoi.sciencedirectorg/10.com/science/article/pii1016/S1470204509702281 s1470-2045(09)70228-1 link to SD original article] [https://pubmed.ncbi.nlm.nih.gov/19747876 PubMed]
==L-Asparaginase, Vincristine, Prednisolone {{#subobject:65692a|Regimen=1}}==
| style="background-color:#d3d3d3" |
|-
|[https://wwwdoi.sciencedirectorg/10.com1016/science/article/pii/0145212679900365 0145-2126(79)90036-5 Henderson et al. 1979 (CALGB 7113)]|{{#subobject:xx|ToDo=1}}1971-1976
| style="background-color:#91cf61" |Non-randomized
| style="background-color:#d3d3d3" |
===References===
# '''CCG 101/143:''' Ortega JA, Nesbit ME Jr, Donaldson MH, Hittle RE, Weiner J, Karon M, Hammond D. L-Asparaginase, vincristine, and prednisone for induction of first remission in acute lymphocytic leukemia. Cancer Res. 1977 Feb;37(2):535-40. [https://cancerres.aacrjournals.org/content/37/2/535.long link to original article] [https://pubmed.ncbi.nlm.nih.gov/264412 PubMed]
# '''CALGB 7113:''' Henderson ES, Scharlau C, Cooper MR, Haurani FI, Silver RT, Brunner K, Carey RW, Falkson G, Blom J, Nawabi IV, Levine AS, Bank A, Cuttner J, Cornwell GG 3rd, Henry P, Nissen NI, Wiernik PH, Leone L, Wohl H, Rai K, James GW, Weinberg V, Glidewell O, Holland JF. Combination chemotherapy and radiotherapy for acute lymphocytic leukemia in adults: results of CALGB protocol 7113. Leuk Res. 1979;3(6):395-407. [https://wwwdoi.sciencedirectorg/10.com/science/article/pii1016/0145212679900365 0145-2126(79)90036-5 link to SD original article] [https://pubmed.ncbi.nlm.nih.gov/297176 PubMed]
# '''CALGB 7612:''' Gottlieb AJ, Weinberg V, Ellison RR, Henderson ES, Terebelo H, Rafla S, Cuttner J, Silver RT, Carey RW, Levy RN, Hutchinson JL, Raich P, Cooper MR, Wiernik P, Anderson JR, Holland JF. Efficacy of daunorubicin in the therapy of adult acute lymphocytic leukemia: a prospective randomized trial by Cancer and Leukemia Group B. Blood. 1984 Jul;64(1):267-74. [http://www.bloodjournal.org/content/64/1/267.long link to original article] [https://pubmed.ncbi.nlm.nih.gov/6375760 PubMed]
# '''DCLSG ALL V:''' van der Does-van den Berg A, van Wering ER, Suciu S, Solbu G, van 't Veer MB, Rammeloo JA, de Koning J, van Zanen GE. Effectiveness of rubidomycin in induction therapy with vincristine, prednisone, and L-asparaginase for standard risk childhood acute lymphocytic leukemia: results of a Dutch phase III study (ALL V); A report on behalf of the Dutch Childhood Leukemia Study Group (DCLSG). Am J Pediatr Hematol Oncol. 1989 Summer;11(2):125-33. [https://pubmed.ncbi.nlm.nih.gov/2665546 PubMed]
!style="width: 25%"|[[Levels_of_Evidence#Evidence|Evidence]]
|-
|[https://wwwdoi.sciencedirectorg/10.com/science/article/pii1016/S0140673669926488 s0140-6736(69)92648-8 Mathé et al. 1969]
| style="background-color:#91cf61" |Non-randomized
|-
*[[Bacillus Calmette-Guérin (BCG)]]
===References===
# Mathé G, Amiel JL, Schwarzenberg L, Schneider M, Cattan A, Schlumberger JR, Hayat M, De Vassal F. Active immunotherapy for acute lymphoblastic leukaemia. Lancet. 1969 Apr 5;1(7597):697-9. [https://wwwdoi.sciencedirectorg/10.com/science/article/pii1016/S0140673669926488 s0140-6736(69)92648-8 link to SD original article] [https://pubmed.ncbi.nlm.nih.gov/4182654 PubMed]
==Cyclophosphamide monotherapy {{#subobject:cd166d|Regimen=1}}==
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