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B-cell acute lymphoblastic leukemia - historical

174 bytes added, 23:09, 13 December 2019
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|[https://www.nejm.org/doi/full/10.1056/NEJM198303103081003 Anderson et al. 1983]
| style="background-color:#1a9851" |Phase III (E-de-esc)
|Modified LSA<sub>2</sub>-L<sub>2</sub>
| style="background-color:#ffffbf" |Seems not superior
|-
|[http://www.bloodjournal.org/content/101/10/3809.long Bostrom et al. 2003 (CCG-1922)]
|style="background-color:#1a9851"|Phase III (E-switch-ic)
|[[#L-Asparaginase.2C_Vincristine.2C_Prednisone|L-asparaginase, Vincristine, Prednisone]]
|style="background-color:#1a9850"|Superior EFS
|-
|[https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2005.05509.x/full Mitchell et al. 2005 (UK MRC ALL97)]
|style="background-color:#1a9851"|Phase III (E-switch-ic)
|[[#L-Asparaginase.2C_Vincristine.2C_Prednisolone|L-asparaginase, Vincristine, Prednisolone]]
|style="background-color:#1a9850"|Superior EFS
|-
|[http://www.bloodjournal.org/content/13/12/1126.long Frei et al. 1958 (ALGB 01)]
|style="background-color:#1a9851"|Randomized (E-switch-ic)|[[#Mercaptopurine_.26_Methotrexate|6-MP & MTX (]]; alternate dosing)
|style="background-color:#ffffbf"|Seems not superior
|-
|[http://www.bloodjournal.org/content/18/4/431.short Frei et al. 1961 (ALGB 03)]
|style="background-color:#1a9851"|Randomized (E-esc)
|1. 6-MP<br> 2. MTX
|style="background-color:#ffffbf"|Seems not superior
|-
|[https://www.nejm.org/doi/full/10.1056/NEJM198602203140803 Evans et al. 1986]
|style="background-color:#1a9851"|Randomized (E-switch-ooc)
|WBRT, then 6-MP & MTX (conventional dosing)
|style="background-color:#d3d3d3"|Not reported
|-
|[https://jamanetwork.com/journals/jama/article-abstract/656675 Selawry & Holland 1965 (ALGB 6313)]
|style="background-color:#1a9851"|Randomized (E-switch-ic)|PO [[#Methotrexate_monotherapy|MTX]]; oral
| style="background-color:#1a9850" |Superior RFS
|-
|[https://jamanetwork.com/journals/jama/article-abstract/343520 Burgert et al. 1969 (ALGB 6311)]
|style="background-color:#1a9851"|Randomized (E-switch-ic)|PO [[#Methotrexate_monotherapy|MTX]]; oral
| style="background-color:#ffffbf" |Seems not superior
|-
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