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B-cell acute lymphoblastic leukemia - historical

612 bytes added, 16:52, 2 January 2019
Mercaptopurine & Methotrexate {{#subobject:6366a6|Regimen=1}}
|style="background-color:#1a9851"|Randomized (E)
|6-MP & MTX (alternate dosing)
|style="background-color:#ffffbf"|Seems not superior
|[ Frei et al. 1961]
|style="background-color:#1a9851"|Randomized (E)
|1. 6-MP<br> 2. MTX
|style="background-color:#ffffbf"|Seems not superior
''Note: this is one of the first combination trials regimens in hematology/oncology and possibly the first randomized trial.''
*[[Mercaptopurine (Purinethol)]]
# Frei E 3rd, Holland JF, Schneiderman MA, Pinkel D, Selkirk G, Freireich EJ, Silver RT, Gold GL, Regelson W. A comparative study of two regimens of combination chemotherapy in acute leukemia. Blood. 1958 Dec;13(12):1126-48. [ link to original article] [ PubMed]
# Frei E, Freireich EJ, Gehan E, Pinkel D, Holland JF, Selawry O, Haurani F, Spurr CL, Hayes DM, James GW, Rothberg H, Sodee DB, Rundles RW, Schroeder LR, Hoogstraten B, Wolman IJ, Traggis DG, Cooper T, Gendel BR, Ebaugh F, Taylor R. Studies of Sequential and Combination Antimetabolite Therapy in Acute Leukemia: 6-Mercaptopurine and Methotrexate. Blood. 1961;18(4):431-454. [ link to original article]
==Mercaptopurine & Prednisone {{#subobject:f609f5|Regimen=1}}==
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