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B-cell acute lymphoblastic leukemia - historical

308 bytes added, 16:13, 2 January 2019
Methotrexate monotherapy {{#subobject:478e97|Regimen=1}}
!style="width: 25%"|[[Levels_of_Evidence#Efficacy|Efficacy]]
|[ Selawry & Holland 1965(ALGB 6313)]
|style="background-color:#1a9851"|Randomized (E)
| style="background-color:#1a9850" |Superior RFS
|[ Burgert et al. 1969 (ALGB 6311)]
|style="background-color:#1a9851"|Randomized (E)
| style="background-color:#ffffbf" |Seems not superior
*Vincristine & Prednisone induction
*[[Methotrexate (MTX)]] IVor IM
# '''ALGB 6313:''' Selawry OS, Holland JF; Acute leukemia group B. New treatment schedule with improved survival in childhood leukemia: intermittent parenteral vs daily oral administration of methotrexate for maintenance of induced remission. JAMA. 1965 Oct 4;194(1):75-81. [ link to original article] [ PubMed]# '''ALGB 6311:''' Burgert EO, Valvo F, Petzold G, Holland JF; Acute Leukemia Group B. Acute lymphocytic leukemia in children: maintenance therapy with methotrexat administered intermittently. JAMA. 1969 Feb 3;207(5):923-8. [ link to original article] [ PubMed]
=Relapsed or refractory=
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