Changes

Jump to: navigation, search

B-cell acute lymphoblastic leukemia - historical

308 bytes added, 16:13, 2 January 2019
m
Methotrexate monotherapy {{#subobject:478e97|Regimen=1}}
!style="width: 25%"|[[Levels_of_Evidence#Efficacy|Efficacy]]
|-
|[https://jamanetwork.com/journals/jama/article-abstract/656675 Selawry & Holland 1965(ALGB 6313)]
|style="background-color:#1a9851"|Randomized (E)
|PO MTX
| style="background-color:#1a9850" |Superior RFS
|-
|[https://jamanetwork.com/journals/jama/article-abstract/343520 Burgert et al. 1969 (ALGB 6311)]
|style="background-color:#1a9851"|Randomized (E)
|PO MTX
| style="background-color:#ffffbf" |Seems not superior
|-
|}
*Vincristine & Prednisone induction
====Chemotherapy====
*[[Methotrexate (MTX)]] IVor IM
===References===
# '''ALGB 6313:''' Selawry OS, Holland JF; Acute leukemia group B. New treatment schedule with improved survival in childhood leukemia: intermittent parenteral vs daily oral administration of methotrexate for maintenance of induced remission. JAMA. 1965 Oct 4;194(1):75-81. [https://jamanetwork.com/journals/jama/article-abstract/656675 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/5896942 PubMed]# '''ALGB 6311:''' Burgert EO, Valvo F, Petzold G, Holland JF; Acute Leukemia Group B. Acute lymphocytic leukemia in children: maintenance therapy with methotrexat administered intermittently. JAMA. 1969 Feb 3;207(5):923-8. [https://jamanetwork.com/journals/jama/article-abstract/343520 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/4303512 PubMed]
=Relapsed or refractory=
LookupUsers, editors, emailconfirmed
24,569
edits

Navigation menu