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B-cell acute lymphoblastic leukemia - historical

1,242 bytes added, 16:00, 2 January 2019
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Maintenance after upfront therapy
===References===
# Evans WE, Crom WR, Abromowitch M, Dodge R, Look AT, Bowman WP, George SL, Pui CH. Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia: identification of a relation between concentration and effect. N Engl J Med. 1986 Feb 20;314(8):471-7. [https://www.nejm.org/doi/full/10.1056/NEJM198602203140803 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/3456079 PubMed]
 
=Late intensification=
==POMP {{#subobject:31219|Regimen=1}}==
{| class="wikitable" style="float:right; margin-left: 5px;"
|-
|[[#top|back to top]]
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POMP: '''<u>P</u>'''urinethol (Mercaptopurine), '''<u>O</u>'''ncovin (Vincristine), '''<u>M</u>'''ethotrexate, '''<u>P</u>'''rednisone
===Regimen {{#subobject:93b1b3|Variant=1}}===
{| class="wikitable" style="width: 100%; text-align:center;"
!style="width: 50%"|Study
!style="width: 50%"|[[Levels_of_Evidence#Evidence|Evidence]]
|-
|[https://jamanetwork.com/journals/jama/fullarticle/344212 Bodey et al. 1976]
| style="background-color:#ffffbe" |Non-randomized, <20 pts
|-
|}
''Note: POMP is still used in maintenance settings; this is marked historic because it is late intensification.''
====Chemotherapy====
*[[Mercaptopurine (Purinethol)]]
*[[Vincristine (Oncovin)]]
*[[Methotrexate (MTX)]]
*[[Prednisone (Sterapred)]]
===References===
# Bodey GP, Freireich EJ, Gehan E, McCredie KB, Rodriguez V, Gutterman J, Burgess MA. Late intensification therapy for acute leukemia in remission: chemotherapy and immunotherapy. JAMA. 1976 Mar 8;235(10):1021-5. [https://jamanetwork.com/journals/jama/fullarticle/344212 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/946184 PubMed]
=Maintenance after upfront therapy=
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