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B-cell acute lymphoblastic leukemia - historical

1,378 bytes added, 13:47, 30 December 2018
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Cyclophosphamide, Doxorubicin, L-Asparaginase, Vincristine, Prednisolone {{#subobject:6edd1f|Regimen=1}}
===References===
# Farber S, Diamond LK, Mercer RD, Sylvester RF, Wolff JA. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N Engl J Med. 1948 Jun 3;238(23):787-93. [https://www.nejm.org/doi/10.1056/NEJM194806032382301 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/18860765 PubMed]
 
==COMP {{#subobject:2ec876|Regimen=1}}==
{| class="wikitable" style="float:right; margin-left: 5px;"
|-
|[[#top|back to top]]
|}
COMP: '''<u>C</u>'''yclophosphamide, '''<u>O</u>'''ncovin (Vincristine), '''<u>M</u>'''ethotrexate, '''<u>P</u>'''rednisone
===Regimen {{#subobject:0ecc0a|Variant=1}}===
{| class="wikitable" style="width: 100%; text-align:center;"
!style="width: 25%"|Study
!style="width: 25%"|[[Levels_of_Evidence#Evidence|Evidence]]
!style="width: 25%"|Comparator
!style="width: 25%"|[[Levels_of_Evidence#Efficacy|Efficacy]]
|-
|[https://www.nejm.org/doi/full/10.1056/NEJM198303103081003 Anderson et al. 1983]
| style="background-color:#1a9851" |Phase III (E)
|Modified LSA<sub>2</sub>-L<sub>2</sub>
| style="background-color:#ffffbf" |Seems not superior
|-
|}
====Chemotherapy====
*[[Cyclophosphamide (Cytoxan)]]
*[[Vincristine (Oncovin)]]
*[[Methotrexate (MTX)]]
*[[Prednisone (Sterapred)]]
===References===
# Anderson JR, Wilson JF, Jenkin DT, Meadows AT, Kersey J, Chilcote RR, Coccia P, Exelby P, Kushner J, Siegel S, Hammond D. Childhood non-Hodgkin's lymphoma: the results of a randomized therapeutic trial comparing a 4-drug regimen (COMP) with a 10-drug regimen (LSA2-L2). N Engl J Med. 1983 Mar 10;308(10):559-65. [https://www.nejm.org/doi/full/10.1056/NEJM198303103081003 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/6338381 PubMed]
==Cyclophosphamide, Doxorubicin, L-Asparaginase, Vincristine, Prednisolone {{#subobject:6edd1f|Regimen=1}}==
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