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B-cell acute lymphoblastic leukemia - historical

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Cytarabine, Daunorubicin, L-Asparaginase, Teniposide, Vincristine, Prednisone {{#subobject:177f43|Regimen=1}}
===References===
# '''JALSG-ALL93:''' Takeuchi J, Kyo T, Naito K, Sao H, Takahashi M, Miyawaki S, Kuriyama K, Ohtake S, Yagasaki F, Murakami H, Asou N, Ino T, Okamoto T, Usui N, Nishimura M, Shinagawa K, Fukushima T, Taguchi H, Morii T, Mizuta S, Akiyama H, Nakamura Y, Ohshima T, Ohno R. Induction therapy by frequent administration of doxorubicin with four other drugs, followed by intensive consolidation and maintenance therapy for adult acute lymphoblastic leukemia: the JALSG-ALL93 study. Leukemia. 2002 Jul;16(7):1259-66. [https://www.nature.com/leu/journal/v16/n7/full/2402526a.html link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/12094249 PubMed]
 
==Cytarabine, Daunorubicin, L-Asparaginase, Vincristine, Dexamethasone {{#subobject:5a7eda|Regimen=1}}==
{| class="wikitable" style="float:right; margin-left: 5px;"
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|[[#top|back to top]]
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===Regimen {{#subobject:245098|Variant=1}}===
{| class="wikitable" style="width: 100%; text-align:center;"
!style="width: 50%"|Study
!style="width: 50%"|[[Levels_of_Evidence#Evidence|Evidence]]
|-
|[https://www.thelancet.com/journals/lancet/article/PIIS014067360761126X/fulltext Pieters et al. 2007 (Interfant-99)]
| style="background-color:#91cf61" |Non-randomized portion of RCT
|-
|}
====Preceding treatment====
*Prednisone pre-phase
====Chemotherapy====
*[[Cytarabine (Cytosar)]]
*[[Daunorubicin (Cerubidine)]]
*[[Asparaginase (Elspar)]]
*[[Vincristine (Oncovin)]]
*[[Dexamethasone (Decadron)]]
====Subsequent treatment====
*MARAM consolidation
 
===References===
# '''Interfant-99:''' Pieters R, Schrappe M, De Lorenzo P, Hann I, De Rossi G, Felice M, Hovi L, LeBlanc T, Szczepanski T, Ferster A, Janka G, Rubnitz J, Silverman L, Stary J, Campbell M, Li CK, Mann G, Suppiah R, Biondi A, Vora A, Valsecchi MG. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): an observational study and a multicentre randomised trial. Lancet. 2007 Jul 21;370(9583):240-250. [https://www.thelancet.com/journals/lancet/article/PIIS014067360761126X/fulltext link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/17658395 PubMed]
==Cytarabine, Daunorubicin, L-Asparaginase, Teniposide, Vincristine, Prednisone {{#subobject:177f43|Regimen=1}}==
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